The results of the X-Ray & ultrasound examinations of the abdominal parenchymal organs in 207 children aged from 3 to 18 years with various forms of TB infection are reported in the article. Аbdominal tuberculosis can occur as an independent disease or as a manifestation of TB infection in combination with other symptoms. The ultrasound reveals the signs of tuberculous infectious process in the absence of other pathological changes according to X-Ray examination. The ultrasonic symptoms of TB lesions of abdominal parenchymal organs include the enlarged liver or spleen, increased echogenicity of the parenchyma of organs, dilation and induration of the intrahepatic vessels or splenic vein walls and calcifications in liver or spleen parenchyma.

The article points out the importance of health, including dental, as a major component in training of officers and the ranks of the Armed Forces of Russian Federation. It emphasizes that according to the Federal Law of March 28, 1998 No. 53-FL "On obligatory military service" the citizens joining the obligatory military service and entering military academies have to satisfy the requirements established for citizens joining the obligatory military service or service under the contract including their health status. The procedure of organizing and performing medical examination of the individuals in question which is defined by the Regulations on military-medical examination of July 4, 2013 No. 565 is under discussion. It is emphasized that orthodontic aid is not rendered in the Armed Forces of Russian Federation due to the absence of specialists.

The article is devoted to the investigation of polymorphism of Helicobacter pylori genes associated with resistance to Clarithromycin (Т2182С, A2142G/С, and A2143G mutation) using the polymerase chain reaction (restriction fragment length polymorphism). The following was investigated: the biopsy material from altered areas of gastric mucosa obtained from outpatients of Kursk city polyclinics and referred to fibroesophagogastroduodenoscopy in order to conduct the differential diagnostics between the gastroesophageal reflux disease and the dyspeptic syndrome. During the research, no cases of А214G/C mutation were detected in the investigated biopsy material. It was found out that Т2182С mutation was detected in 10.3% of cases, while mutation A2143G - in 13.79% of cases. Thus, the incidence of НР mutations related to the resistance to Clarithromycin is 24.13%, which is the rationale for the use of reserved 1^st- and 2^nd-line eradication schemes to treat НР-associated diseases in city of Kursk.

The aim of this work is to study the quantitative characteristics of extragenital injuries in female children who have suffered from sexual violence. The experimental group included 245 cases, where victims had suffered from sexual violence; the control - 275 cases, where the victims were subjected to outrage without sexual violence. The grounds for classifying the cases into the sampling frame were investigative data. The statistical analysis was performed using the following criteria: the Kolmogorov-Smirnov (λ), the Mann-Whitney (U), Kruskal-Wallis (H). We also conducted the Wald’s test of heterogeneous consistent statistical pattern recognition procedure, according to which the results of differential diagnostic factors were obtained. Statistically significant criteria were established for the differential diagnosis according to the quantitative characteristics of injuries between episodes of sexual violence and in the absence thereof.

In this research paper a microbial spectrum of amniotic fluid and histological changes in placenta in 255 parturient women with immature delivery were studied. Newborns of these mothers had respiratory disorders. The 1st group included 87 children with congenital pneumonia, the IInd group consisted of 83 children with respiratory fetal-distress and the IIIrd group contained 85 newborns with both congenital pneumonia and respiratory fetal-distress. The semination of amniotic fluid in parturient women was found in 29.0% and the semination of placenta was identified in 24.7% cases. The amount of colonies of opportunistic flora in the amniotic fluid equal to 106 and more was revealed in the 1st group in 83.9% of parturient women and in the IIIrd group it was in 74.1% women, and in the IInd group it was in 42.2% parturient women. The bacterial and fungal flora (29.5%) was prevailed. The degree of opportunistic flora colonization in placenta of parturient women being equal to 106 and more was found in the 1st group in 82.6% and in the IIIrd group it was in 78.8% cases, in the IInd group it was in 57.1% women. The bacterial and fungal flora was identified in 18.3% patients. The half of parturient women in the IInd and IIIrd groups and 1/3 of the Ist group were revealed immature placenta with signs of chronic placental insufficiency.

The examination of 160 patients with severe asthma who were hospitalized into the pulmonology department of Kursk regional clinical hospital revealed the following phenotypes of the disease according to the GINA, 2016 .: allergic, non-allergic, steroid, asthma in smokers, asthma and obesity, asthma combined with COPD (chiasm syndrome). CHD was diagnosed in 33% of patients with non-allergic asthma and in 65% with the chiasm syndrome accompanied with rhythm disorders as well as in 50% of patients with COPD + BA. Obesity is reported in 77% of female patients with severe asthma and 80.1% of these patients had hypertension. A negative correlation between indicators of FEV1 / FVC ratio, duration of disease, and smoking experience index was established. Infection was the main trigger factor in exacerbations of severe asthma (47.4%). 33.8% of patients were given the inadequate standard asthma outpatient therapy; only 12% of patients with the chiasm syndrome receivedantibiotic therapy in exacerbations of COPD.

Possible conditions and reasons of more prolonged period of patient‘s hospitalization after urgent endoscopic cholecystectomy performed due to different acute cholecystitis types were presented in the article. It was revealed that different combinatios of premorbid factors, individual differences in acute disease сlinical picture, and intraoperative technical peculiarities correlate with postoperative dysorders resulting in various nonspecific clinical symptoms. It is assumed that longer recovery is determined by hidden protracted disorders of systemic homeostatic regulation against the background of intraoperative stress that had not been diagnosed by routine methods of body monitoring. The investigation results show that neural analysis allows to detect patients with the highest possible level of postoperative disorders and to plan the ways of their minimizing due to modulation of modifying factors relating to endoscopic cholecystectomy.

The research conducted by the methods of contact computer biomicroscopy and cross-polarization optical coherent tomography allowed to assess the microcirculation, and inflammatory and fibrosing process in the oral mucosa in patients with chronic inflammatory bowel diseases (Crohn's disease and chronic nonspecific ulcerative colitis), to determine the frequency of certain morphological features and to reveal the differences between the individuals examined. The increase in the arteriolar and venular diameters of capillaries, deformation, haziness, and blurriness of microvascular picture of the oral mucosa in patients with chronic inflammatory bowel diseases showed the angiopathy development, being higher in patients with Crohn's disease as compared to individuals suffering from chronic nonspecific ulcerative colitis. Microstructural changes of the oral cavity mucosa in patients with Crohn's disease in comparison with the control groups and individuals with chronic ulcerative colitis are characterized by an excessive accumulation of collagen in the connective tissue stroma.

The comparative assessment of the intramural nervous apparatus of small intestine in forming the enteroanastomosis "side - to - side" and "end -to-end" was carried out by the experiment on dogs using the general morphological and neurohistochemical techniques. The various degree of neurones bodies changes, and also myelinic and amyelinic nervous fibers, some of which had been injured (and even cut off) during surgical interventions, while others had developed as a reaction to ischemia in an anastomosis zone, was established. The greatest morphological differences between two compared anastomosis were defined 7-10 days after the experiment had started. They concerned both a condition of neurocytes of intramural ganglions, and the processes of the damaged terminal ends regeneration. The smaller degree of edema and evidence of destructive changes allow concluding that the anastomosis "side - to - side" provides more reliable anastomosis that proves the advantages of its formation.

It is known that the proteolysis disorder and changes in metabolism of extracellular matrix proteins cause the process of remodeling heart muscle, which is one of the risk factors for coronary heart disease (CHD). Matrix metalloproteinases (MMPs) are responsible for the process of proteolysis. Single nucleotide substitutions in genes encoding MMPs may influence the functional activity of enzymes. The aim of this study was to investigate the association of polymorphisms -1612 5A/6A (rs3025058) of MMP3 gene and 2003G>A (rs17577) of MMP9 gene with the risk of CHD in population of Central Russia. We studied DNA samples obtained from 946 subjects, including 256 CHD patients and 248 sex- and age-matched healthy individuals. The polymorphisms were genotyped through a real-time PCR using TaqMan allele-discrimination assays. The comparative analysis showed no difference in allele and genotype frequencies of MMP3 and MMP9 polymorphisms between the case and control groups. The study showed that polymorphism -1612 5A/6A of MMP3 gene and polymorphism 2003G>A of MMP9 gene are not associated with coronary heart disease in population of Central Russia.

The most common complication of the gastrointestinal organs being operated on in the postoperative period is the failure of intestinal suture (11% of the total number of complications). In order to solve this urgent problem, new polymeric materials to reinforce a suture line are being developed. The aim of the research was to study the physical and mechanical properties and characteristics of newly designed polymeric membranes used to strengthen and seal colorectal sutures. The results of investigating the microrelief, the degree of adhesion, degradation rates, and other properties of new polymer film membranes allow predetermining the effectiveness of applying the implants studied in abdominal surgery.

Using the proper type of endoprosthesis which is combined with medicines reducing inflammation in the implantation area could decrease relapses as well as improve quality of treatment. We used endoprosthesis «Parietene ProGrip» when working with laboratory animals. The animals of the experimental group were given the solution of Solcoseryl every other day within 90 days, at first intraoperatively, then intraperitoneally. The animals from the control group didn't get the drug. The combination of «Parietene ProGrip» endoprosthesis together with Solcoseryl created special conditions for reducing inflammation area, increasing pool of fibroblasts. A capsule made from compact fibrous connective tissue formed a solid carcass whose main function was mechanical: keeping together filaments of endoprosthesis. It will set a lasting link with surrounded tissues and improve management results at the end.

The problem of managing patients with deep necrosis of the skin and soft tissue remains relevant. Selecting necrectomy volume, timing of its implementation, the boundaries of performing surgical incisions are still not fully resolved. Necrosectomy against the background of the DSLET combination (10 mg / kg) and serotonin adipate (4.5 mg / kg) resulted in a decrease in the severity and prevalence of alternative changes in simulating deep necrosis of the skin and soft tissues. On the 3d day the granulation tissue was formed in wound edges. By the end of the experiment the whole damage area was formed by connective tissue with the newly produced dense collagen fibers indicating the maturation of connective tissue in the generating scar. The suggested method results in a maximum decrease in mortality to 16.6% and also reduces the lethality of animals by 10.9% as compared to the experimental group without necrectomy.

The article presents the results of morphological and histological research of mucosal status of the tracheobronchial tree of healthy adult people. The methodology has been detailed and includes histological, histochemical research methods (six-stepped histological processing, hematoxylin-eosin stain) and the data-processing results. The study results revealed that the mucous membrane consists of the multi-row ciliated columnar epithelium and lamina propria. The next layer is submucosa, which has uneven thickness along trachea and bronchi. Тhere is the systemic asymmetry of bronchial mucosa with right-side domination. The results indicate that the main right bronchus has more intensive functional load, because its level of systemic organization allows the most rapid functional changes in case of negative impacts.

An experimental study of the dynamics of zinc accumulation within 168 hours in blood plasma, packed red blood cells, and liver of Wistar rats was conducted. The study included small-sized compounds that had been prepared by the modified condensation method: Zn(OH)₂ (2-3 nm), ZnO (0.9 - 1 μm), and as a comparative compound - ZnSO₄. The substances were administered to rats intragastrically at dosage 100 mg/kg in terms of zinc. The study revealed the best dynamics (1.5-2 times as compared with ZnSO₄ and ZnO) of zinc hydroxide accumulation in packed red blood cells. The ability of zinc hydroxide nanoparticles to more rapid penetration into blood plasma was revealed. Zinc levels in liver tissue of the group having received Zn(OH)₂ was significantly lower (p <0.05) as compared to the groups which had been administered ZnO and ZnSO₄. We concluded that nano Zn(OH)₂ is of great potential efficacy as a perspective compound in biopharmaceutical applications.

The paper presents the application of Shewhart control charts in the annual review of medicinal products quality in order to analyze the production process stability and to use the indicators of process capability for the purpose of its enhancement. The authors presented the sequence of applying Shewhart control charts to identify the various states of manufacture processes and calculate reproducibility and suitability indices, enabling to interpret the input data for effective assessment of drug quality and proper management decisions. By example of some solid, liquid, and soft medicinal forms and by means of assessing the statistical characteristics used in drug quality review, we identified the possibilities of optimizing the production process, grounded the required management dicisions, confirmed the production process stability, identified the need for stabilizing the mean value, and established the causes of the production process uncontrollability.

The anthropometric data are used as indicators of physical development of military-age men, while the data on a blood group are not fully applied. Whereas this system can be informative and practically significant in people having normal health indicators. The article examines the relationship between anthropometric characteristics and blood groups. On the basis of descriptive statistics the received data show the variability of anthropometric signs and blood group of iso-serologic ABO and Rh systems in Russian military-age men of the Republic of Karelia, these can serve as a standard constitution. The data on blood group can be used as universal and easily observed indicators of human physical development. It is expedient to use this information together with other phenotypic markers as an additional diagnostic criterion.

The research is aimed at detecting and exposing the mechanisms of functioning child’s health protective factors, by which we mean several psychosocial factors, specific on each stage of a child’s, mother’s and the whole family’s course of life in the context of social environment. This article presents the results of studying a correlation between the maternity readiness style, the quality of mother-infant interaction during first 6 months and psychosomatic health of a child. It has been established that the experience of early emotional deficiencies of an infant, accumulated during fetal stage and first 6 months after birth, creates risk factors to psychosomatic health. It has been found out that understanding of the corporal experience of pregnancy is closely connected with acceptance of motherhood, which is reflected in semantic and temporal features of subjective image in a person’s course of life.

This article discusses the prospects of using the theoretical construct of person’s vital metacompetence in mental health research. In this work the concept of person’s vital metacompetence is considered as an active and purposeful implementation of person’s vital metacompetence in social and psychological space of an individual. System units of vital metacompetence involve vital competence as the ability to cope effectively with problematic situations related to health hazards in social and psychological space of an individual. Systemic properties of vital metacompetence act as criteria for the level of its formation which, in turn, determines the stability of treatment results and, therefore the overall pattern of the individual life realization.