Objective. To evaluate the clinical efficacy of focused shockwave therapy and superinductive magnetotherapy combination in the treatment of plantar fasciitis (heel spur). Materials and methods. 70 patients with plantar fasciitis (heel spur) were under observation. Depending on the clinical picture, the patients were divided into three groups: the main group (n=20) - patients who underwent superinductive magnetic therapy and shockwave therapy; comparison group (n=40) - patients who underwent shockwave therapy; control group (n=10) - patients who underwent local hormone injection with anesthetic. Results. It was found that the complex treatment of plantar fasciitis (heel spurs) with focused shockwave therapy and superinductive magnetic therapy allows to obtain satisfactory results in 90% of patients at the end of the 2nd week after the treatment and 100% results by the end of the 4th week after the treatment. This is significantly higher than with shockwave therapy (SWT) alone (p<0.05). Pain relief in plantar fasciitis (heel spur) is directly related to the presence of edema in the heel area. Patients with edema should be treated with superinductive magnetic therapy before SWT. Conclusion. The treatment results with shockwave therapy only and combination SWT with superinductive magnetotherapy(SIS therapy) will optimize the treatment strategy for various patients with plantar fasciitis (heel spur).

The incidence of arterial hypertension (AH) in women increases significantly with the onset of menopause. Age-related hypoestrogenism leads both to an increase in blood pressure (BP) and to a violation of its daily profile. It can lead to impaired cerebral blood flow. Objective: to study the features of cerebral disorders in women in the perimenopausal period with and without hypertension using rheoencephalography, as well as their relationship with some indicators of the daily blood pressure profile. Materials and methods. A clinical and instrumental examination of 190 women in the climacteric period (141 people with hypertension and 49 without hypertension) was carried out, who were divided into groups depending on the presence of hypertension and the period of perimenopause. Instrumental research included 24-hour blood pressure monitoring and rheoencephalography. Results. The onset of menopause was accompanied by an increase in the degree of arterial hypertension, with an increase mainly in systolic blood pressure. Changes in its daily profile was also noted, especially insufficient or excessive decrease at night, as well as an increased speed and magnitude of the morning rise both in women with hypertension and without it. The revealed disorders were more pronounced in postmenopausal women and were accompanied by changes in cerebral circulation, which can lead to ischemic and hemorrhagic cerebral complications. Conclusion. Comparison of indicators of rheoencephalography and daily monitoring of blood pressure in menopausal women revealed changes in cerebral circulation, most pronounced in the presence of arterial hypertension and after menopause.

Objective: to study the physical and mechanical properties of two-component spongy hemostatic implants. Materials and methods. Experimental group of two-component sample №1 based on Na-CMC was compared with samples: №3 Surgicel, №2 Tachocomb. To determine the residual strain, the specimens were compressed followed by fixation of the thickness recovery. To determine sorption capacity, the sample was weighed, placed in distilled water, transferred to a prepared test tube, centrifuged, and the sponge mass was measured. Porosity was determined in the same sequence, but the implants were immersed in orthoxylene. To determine adhesion, specimens were placed between two plates and the force of separation of the implant from the surface of the plate was recorded. Results. The porosity coefficient of specimen №1 was greater than №2 and №3 by 0.61 and 0.87. Adhesive properties of sample №1 are 0.28 greater than №2 and 0.45 greater than №3. The sorption capacity per unit mass of sample №1 is 2.5 times greater than №2 and 2.47 times greater than №3. The residual strain values of sample №1 and №2 were 1.18 and 2.87 less than №3. The values of sample №1 were higher than №2 by 1.69.

The article aims at presenting the review of literature data concerning mechanisms, diagnostic methods, and preventive approaches for cardiovascular toxicity induced by chemotherapy and target drugs. The review is devoted to the currently important issue of cardiotoxicity with antineoplastic therapy. Modern cytostatic agents cause clinically significant myocardial damage, which definitely impair the quality of life and decrease the life expectancy in oncological patients. Compared to traditional chemotherapy, target cancer therapy is a new strategy which inhibits key molecules of signal pathways participating in carcinogenesis and tumor spread. Target cancer therapy is characterized by lesser unfavorable effects on normal cells and considered the future of chemotherapy. However, cardiovascular toxicity induced by target cancer therapy sometimes becomes a critical issue in patients administered novel antineoplastic agents. Cardiac oncology is a new sphere of medicine which comes under scrutiny of experts despite the fact that many mechanisms of cardiovascular complications for the antineoplastic therapy have not been thoroughly studied. The current review presents the state-of-the-art information concerning mechanisms, diagnostic and monitoring problems for cardiovascular safety, a contemporary view of preventing cardiotoxicity induced by chemotherapy and target drugs.

Objective. To assess the nature of changes in the types of myocardial remodeling of the left ventricle in patients of middle, elderly and senile age with acute ST-segment elevation myocardial infarction within 6 months after successful revascularization. Materials and methods. The study included 132 patients with a diagnosis of acute ST-segment elevation myocardial infarction, in combination with arterial hypertension who were divided into 3 groups depending on age: middle-aged patients (45- 59) - 48 people, elderly patients (60-74) - 44 people, senile patients (75-89) - 40 people. The type of left ventricular remodeling was assessed by determining the relative wall thickness and mass index of the left ventricular myocardium with doppler echocardiography in the first 12 hours after the onset of anginal syndrome, and after 6 months. All patients underwent percutaneous coronary intervention. Results. It was found that initially with the development of acute myocardial infarction, senile patients more often had eccentric left ventricular hypertrophy (in 25%) than patients of middle (6%) and elderly age (11%). After 6 months, in middle-aged patients, the type of remodeling eccentric hypertrophy increased to 14%, in the elderly - up to 23%, in senile patients - up to 50%. Conclusion. In patients who have undergone acute myocardial infarction against the background of traditional therapy and rehabilitation, there are changes in the types of left ventricular myocardial remodeling: eccentric hypertrophy increases in middle age up to 14%, in the elderly - up to 23%, in senile age - up to 50%.

To study the periodontal tissues, inflammatory and dystrophic diseases of which more than 50% of the population of the globe occur, the following methods are used: rheoparadontography, laser Doppler flowmetry, ultrasonic high-frequency Dopplerography (echoosteometry) and others which are often inaccessible for the public health institutions because of the need in special expensive equipment, training and preparation of the equipment. The aim of the work was to correlate the assessment of the periodontal tissues condition in chronic generalized periodontitis with the help of modern methods of functional diagnostics and with the help of the test allowing to estimate the gingival capillaries resistance. 152 adult patients 45-56 years old were examined, 36 of them were not diagnosed with periodontal pathology, 116 patients had chronic generalized periodontitis of different severity degrees. Capillaroscopy, laser Doppler flowmetry, Kulazhenko's test, peripheral blood circulation index in the gingiva were applied in all patients to assess the morphofunctional state of the periodontal tissues. In people suffering from chronic generalized periodontitis the state of the periodontium using the mentioned research methods was also evaluated one month after the completion of the complex treatment. It is shown that the test of Kulazhenko suggested in the last century and the technique of the index evaluation of the peripheral blood circulation in the gingival tissues based on it clearly and reliably correlate with the indices obtained with the help of modern appliances for hemocirculation studies. Therefore, these techniques should retain their relevance for practical dentistry, especially since the use of Kulazhenko's test has a significant positive therapeutic effect on periodontal tissues in its inflammatory pathology, and the use of IPCD allows to objectively assess the effectiveness of therapeutic and preventive measures, including during the dispensary of periodontological patients.

Objective: to identify the pattern of age-related changes in the cerebral index and to determine the dynamics of transverse and longitudinal thalamic dimensions in mesocephalians according to magnetic resonance imaging. Material and methods. The data of magnetic resonance imaging of the brain of 78 people (37 men and 41 women) were analyzed. Depending on the age, all the subjects were divided into two groups. Group I consisted of 43 people (21 men and 22 women) of the first period of adulthood (29.19±0.73 years), group II - 35 people (16 men and 19 women) of senile age (78.97 ± 0.61 years). The cranial width index and cranial length index were calculated from the outermost protruding points on the axial section in 3D reconstruction mode. Morphometric examination of the thalamus included determining its linear dimensions in the axial plane: transverse (distances from the most distant medial and lateral points) and longitudinal (distances from the most distant anterior and posterior points). Results. Analysis of head index values revealed their statistically significant prevalence in men compared to women in the first period of adulthood (p<0.01). In old age, there were no sex differences, but there was a tendency for the values of the head index to prevail in men compared to women (p>0.05). Transverse and longitudinal dimensions of the thalamus in both hemispheres were found to be predominant in both males and females in the first period of adulthood in comparison with old age (p<0,01). When comparing the thalamic dimensions of the right and left hemispheres, both in the first period of adulthood and in senile age, no statistically significant differences in parameters were found, but there was a tendency for their predominance in the left thalamus (p>0.05). Conclusion. The results obtained in this study add to the information available in the scientific literature on age-related changes in the cerebral index as well as on the morphometric characteristics of the thalamus in both sexes during the first period of adulthood and in old age, making it possible to implement a personified approach in medical practice as well as to use these data in further clinical and basic research.

The aim of the study was to provide a comparative assessment of reparative osteogenesis activity and neutrophil function when thymogen, dalargin, Gly-His-Lys (GHK) peptides and their paired combinations were injected into the experimental fracture area. Materials and methods. Peptides were administered to Wistar rats in the area of fracture for ten days from the day of injury. Equimolar single doses of the drugs were used: dalargin - 1.2 µg/kg, while thymogen and GHK were injected in a dose of 0.5 µg/kg weight. Reparative activity of osteogenesis was assessed histologically and radiologically. Phagocytic and oxygen-dependent activity of the blood neutrophils was determined. Results. All peptides and their paired combinations increased the activity of reparative osteogenesis. Even more pronounced bone repair activity was observed after the injection of GHK peptide in combination with dalargin or thymogen with maximum intensity in animals treated with combined administration of GHK and dalargin. The fracture of the femur bone in experimental rats was also accompanied by a decrease in phagocytic and oxygen-dependent activity of neutrophils. The peptides increased the indices of neutrophils activity more markedly when using paired combinations of peptides and with the manifestation of a corrective effect in animals receiving combined administrations of GHK and dalargin. Conclusion. Synergistic action of Gly-His-Lys peptides, thymogen and dalargin significantly enhances reparative and stimulating neutrophil function in tubular bone fractures and can be used to activate reparative osteogenesis and neutrophil bactericidal activity.

In the assortment of pharmaceutical organizations, along with registered medicinal products (MP), there is a fairly large number of biologically active additives (BAA). In connection with the huge growth rate of the number of dietary supplements in the pharmaceutical market, testing their quality, efficacy, safety and the development of new research methods in this area is of particular importance. Objective: to determine the content of inorganic impurities (lead, cadmium, arsenic, mercury) in the selected objects. As a result of studying the assortment of dietary supplements, as well as regulatory documentation, the following objects were selected for the study: Mumie Altai "Balsam of mountains", tablets, manufacturer - LLC "Farm-product", Russia, Barnaul, dietary supplement for food - a source of humic acids, not being a medicine, were obtained through the pharmacy network. Spirulina VEL®, tablets, manufactured by LLC - "V-MIN", Russia, Moscow region, Sergiev Posad, dietary supplement for food - a source of phycocyanins and beta-carotene, not being a medicine, were obtained through the pharmacy network. Materials and methods. For the determination of lead, cadmium and arsenic, the method of atomic absorption spectrometry was chosen by measuring the absorption of radiation at a certain wavelength corresponding to the element to be determined. To determine mercury, we used an extraction-photometric method based on the formation of a complex compound of mercury (II) -ion with dithizone and measurement of the degree of absorption of non-monochromatic light by the formed complex. Results. The content of lead-ion, cadmium-ion and mercury-ion does not exceed the maximum permissible levels for both samples in accordance with the requirements of both the Technical Regulations and XIV State Pharmacopeia, while the content of arsenic exceeds for the Mumie sample in accordance with the requirements of XIV State Pharmacopeia, but does not exceed according to the requirements of TR CU 021/2011. Conclusion. It was found that the content of heavy metals and arsenic does not exceed the permissible level in accordance with the requirements of the Technological Regulations of the Customs Union 021/2011 for both samples. If we compare with the requirements of General Pharmacopoeia Monograph 1.5.3.0009.15 XIV State Pharmacopeia, then there is an excess in the permissible level of arsenic in the Mumie sample.

The article is devoted to the research of the composition of elements in the aerial part of a poorly studied species of the genus Leonurus L. - Leonurus deminutus V. Krecz, the most common in Central Siberia. This species belongs to the plants of folk medicine and is used as a sedative and antihypertensive agent in the form of infusions, tinctures and fresh juice. Objective: to study the composition of elements of the aerial part of L. deminutus of Central Siberian flora. Materials and methods. The object of the study was the aerial organs of L. deminutus harvested during the flowering period in 2020 in the Irkutsk Region. To study the composition of elements we used the method of inductively coupled plasma mass spectrometry (ICP-MS) using a quadrupole mass spectrometer “Agilent 7500 ce”. Results. 72 elements were found in the aerial organs of L. deminutus , 9 of which belong to the group of macroelements (Al, K, C, Si, Mg, Na, S, P, Cl), the rest belong to the group of micro- and ultramicroelements (Fe, Mn, Zn, Cu, V, Cr are the most valuable). The content of heavy metals and arsenic complies with the permissible standards regulated by the XIV State Pharmacopoeia of the Russian Federation. Conclusion. The composition of elements in the aerial organs of L. deminutus was studied for the first time. The data obtained indicate the promising use of the studied species as a reserve source of minerals.

At present, the issue of creating and introducing into medical practice domestically produced drugs, the quality of manufacture of which is established using objective, highly sensitive optical physical and chemical methods, becomes relevant. Objective: to develop a spectrophotometric method for analysis of propranololol in the ointment "Propranozol" made on the basis of "Tizol" gel. Materials and methods. Pharmaceutical substance propranolol, gel "Tizol", soft dosage form "Propranosol" containing 0.5% of beta-adrenoblocker in titanium-containing base were used in the study. The analysis was carried out by spectrophotometric method in the near ultraviolet region using a domestic device SF-2000. The method was validated according to State Pharmacopoeia of the Russian Federation, XIV edition, General Pharmacopeia Article 1.1.0012.15 "Validation of analytical methods". The developed method was validated according to the following metrological characteristics: specificity, linearity, reliability and precision. Statistical processing of the measurement results was performed according to the requirements of SPh RF XIV edition by methods of modern mathematical statistics (regression analysis), using a personal computer and MSOffice application package. Results. When studying propranolol absorption spectra in the ultraviolet region it was found that spectrophotometric analysis of this compound is rationally performed at a wavelength of 290 nm. The content of propranolol in the soft dosage form, found by the equation of the calibration graph, is within the range of 0.0470-0.0582 g, which corresponds to the allowable standards of deviation given in the regulatory documentation. Conclusion. During the experimental study optimal conditions were chosen and the method of spectrophotometric quantitative determination of propranololol in the ointment "Propranozol" was developed with the relative error not exceeding ± 1.60 %.