The aim of the study was to assess the level of cytokines and components of the complement system in patients with arterial hypertension, depending on the nature of the damage to target organs. Patients with arterial hypertension of grade 2, risk 3 were divided into 3 groups depending on the target organ damage: 21 patients who had the left ventricular myocardial hypertrophy (LVH), 20 patients with LVH and asymptomatic atherosclerosis and 21 patients with LVH and chronic stage 3 kidney disease. In patients with arterial hypertension with subclinical lesions of target organs, changes in the representativeness of the cytokine immunity and the complement system were found: more pronounced changes in the cytokine link in patients who combined the left ventricular hypertrophy with asymptomatic atherosclerosis; patients combining the left ventricular hypertrophy and chronic kidney disease are characterized by more pronounced changes in exponent of the system of complement.

The article analyzes the effect of chronic generalized periodontitis and the methods of its treatment on the life quality of patients which has been assessed by using the Oral Health Impact Profile (OHIP-14) as an oral health questionnaire validated in Russia. It was shown that the initial state of patients with chronic generalized parodontitis was characterized by a marked decrease in the life quality and its criteria in comparison with the indices of healthy individuals. It has been established that the course application of ozone in combination with transcranial magnetotherapy in patients with chronic generalized periodontitis in comparison with traditional treatment is a more effective therapeutic method that provides reliable positive dynamics of subjective signs and basic dental indices. The combination of the revealed positive dependences between the indicators of the dental status and the domains of the life quality proves the informative use of the "OНIP-14" questionnaire as a criterion for choosing the method of therapy and evaluating the clinical effectiveness of the ongoing treatment of chronic generalized periodontitis.

To examine the role of educational programs in modifying certain risk factors in patients with arterial hypertension (AH), working at a large industrial enterprise, 185 patients with AH were selected. The patients were randomized into two groups: 125 persons were included into the main group; the remaining 60 - the control group. All the patients initially and a year after the supervision had a questionnaire and full clinical and diagnostic examination with the individually chosen scheme of hypertensive therapy. The intervention group patients additionally received a training course in «Health School " that led to raising awareness of AH, changing eating habits and alcohol consumption, as well as the positive dynamics in correcting the behavioral risk factors such as low physical activity and smoking.

The importance of vascular wall rigidity, diastolic dysfunction of left ventricle in development of coronary heart disease in patients with chronic kidney disease is investigated. The possibility of coronary heart disease development in patients with pathology of kidneys, despite the absence of hemodynamic significant stenosis of coronary arteries according to the results of coronarography is established,the importance of detecting diastolic dysfunction as an early marker of developing heart failure in patients with combined pathology is shown. Studying diastolic dysfunction and vascular wall rigidity can help to define more presisely the degree of cardiovascular risk in these patients, and their monitoring in dynamics can be used as an additional objective criterion for evaluating therapy efficiency.

A comparative characteristic of inpatient treatment effectiveness, hemodynamic parameters, homeostasis parameters in patients with a local odontogenic infection (LOI) in the presence of chronic respiratory diseases (main group), and patients with LOI with no background pathology (control group). Respiratory diseases in patients of the main group were represented by chronic obstructive pulmonary disease (COPD, 85.3%), bronchial asthma and pulmonary tuberculosis (14.7%). In patients of the main group, compared to the control group, there was a significant decrease in cardiac stroke volume (61.8±1.64 ml), an increase in systolic blood pressure more than 130 mm Hg, and an increase in heart rate (85.1±1.79 per min.). In general, changes in the indices of cardiac hemodynamics and homeostasis in patients with LOI and background diseases of the respiratory system had the compensated nature and did not affect significantly the development of complications, the course and outcome of local purulent inflammatory process (p>0.05).

The study objective is to evaluate Tofacitinibum (TOFA) impact on the vasomotor endothelial function and arterial stiffness in patients with rheumatoid arthritis (RA). 26 patients were examined; they had active RA and either inefficient prior methotrexate therapy or contraindications to its administration. Initially and after 6 months of TOFA (10 mg/day) treatment, the pulse wave contour analysis and reactive hyperemia test were performed. It was revealed that TOFA had a vasoprotective impact on large elastic vessels (4-fold (p=0.001) and 1.3-fold (p<0.01) decrease of augmentation and stiffness indices, respectively), large vessels (1.8-fold increase in inter-channel phase shift value (p=0.008)) and small muscular arteries (normalization of amplitude occlusion parameters and reflection index which reached the control group values).

The article presents the data on the possibility of obtaining additional diagnostic information about the reactions of the systemic regulation of the body under stressful conditions implemented as a part of the stress-test in patients with coronary artery disease: stable exertional angina. The implementation of an alternative approach to the assessment of adaptation processes arising against the background of measured physical activity is based on the assessment of the shifts in the topology of the entropic attractor model of the sinus heart rate reflecting the phenomenon of systemic homeokinesis. Against the background of the transition process in systemic regulation during stress-test, at the attractor structure has been revealed the development of the heart rate entropy, being a complex object, with the effects of activation and consolidation of its levels, which are significantly more pronounced during the formation of myocardial ischemia. The proposed digital indicators reflecting the identified topological changes can be used for an objective quantitative diagnosis of the phenomenon of destabilization of the systemic body resistance during the exacerbation of acute somatic pathology.

The aim of the study was to assess the level of cytokines and components of the complement system in blood plasma and in gingival pocket wipe-sample in teenagers with chronic generalized catarrhal gingivitis against the background of the use of Parodontocide gel. 42 teenagers aged from 14 to 17 years with chronic generalized catarrhal gingivitis were under constant observation. They were divided into 2 groups: patients of the 1st group received basic treatment, and patients of the 2 groups additionally received Parodontocide gel as a part of the basic therapy. Before therapy and after 2 weeks, the levels of tumor necrosis factor alpha (TNFα), IL-2, IL-1α, IL-6, IL-8, interferon α (IFα), IL-18, IL-4, and IL-10, interleukin-1 receptor antagonist (IL-1Ra), C₃-, C₃- C₄-, C₅-, C_5a-components of complement, H factor, C₁-inhibitor and sIgA were determined. The use of basic therapy only in teenagers with chronic generalized catarrhal gingivitis does not have an adequate immunocorrective effect on the cytokine level and the complement system, but requires the use of additional pharmacological correction, the gel-like drug «Parodontocid» is effective in this regard.

The influence of traditional therapy supplemented with polymuramil on the cellular immunity of patients with perianal fistulas was investigated. It was found that the development of pararectal fistulas is accompanied by forming a pronounced imbalance in lymphocyte subpopulations. Summarizing the effectiveness of treatment options in patients with chronic paraproctitis according to the indicators different from the normal level revealed that the additional appointment of polymuramil to the standard treatment plan allowed normalizing 70.0% and correcting 10.0% of the indicators changed. Thus, the additional appointment of polymuramil to the standard therapeutic plan leads to a pronounced correction of impaired immunological parameters, which affects the clinical effectiveness of the treatment in this category of patients.

The development of 3D technologies, the wide spread and improvement of 3D printers, elaboration and use of new materials and their combinations have contributed to general availability of 3D printers in medicine. The use of 3D technology in surgery is possible in the following areas. First of all, there are a lot of various implants, which are widely used in dentistry, traumatology and reconstructive surgery. Secondly, 3D models are suitable for simulating surgical operation in complex cases. Thirdly, scanning and printing of organs and tissues with living cells, the so-called bioprinting, is progressively used. Fourthly, there is an experience of using 3D printers for creating medical instruments. Finally, 3D printers have been properly investigated to create various endoprostheses. Thereby, the perspective of 3D technologies is huge. They will necessarily be one of the dynamic areas in medicine, particulary in surgery in the nearest future.

The results of the experimental study of the abdominal wall after supraaponeurotic endoprosthesis with a lightweight polypropylene implant with and without introducing autoplasma enriched with platelets into the implantation zone conducted on chinchilla rabbits. The study of the abdominal wall strength and elasticity was carried out with a tensile testing machine REM-02-1. The indicators of relative elongation in standard and breaking load were recorded as well as the breaking load of tissue. The results of the study showed that introduction of autoplasma enriched with platelets can increase the elasticity and strength of the abdominal wall. The developed technology of stimulation of reparative processes in the abdominal wall tissue after endoprosthesis is technically simple, economically feasible and safe for patients. The conducted researches allow recommending the stimulation of reparative processes in hernioplastica with autoplasma enriched with platelets for further clinical tests.

The article is devoted to investigating the possible hemostatic activity of carboxymethylcellulose 3% gel. The mechanism of action is based on the interaction of colloids: the hydrophilic groups of carboxymethylcellulose absorb the liquid part of blood - plasma and, on the other hand, the gel is a matrix that retains the blood cells, forming a lattice for developing a platelet clot. This fact was confirmed by the results of experiments in vivo and in vitro: the drug reduced the clotting time by 36% (109.15 s.) in case of liver injury and by 27% (89.85 s.) in case of spleen injury (p <0.05); it reduced blood loss by 14% (67 mg.) on the model of liver injury and 16% (65.8 mg) on the model of spleen injury (p <0.05). This opens up new horizons for using this implant in cases of parenchymal bleeding as a drug with combined action: it has both hemostatic and anti-adhesive effects.

The review considers the problem of choosing an effective antibiotic for starting and purposeful antimicrobial therapy of purulent-necrotic complications of diabetic foot syndrome. It is shown that empirical antibacterial therapy should be carried out taking into account the previous treatment, clinical data, existing clinical, national and international recommendations, as well as based on the data of local bacteriological monitoring, and taking into account the possibility of the influence of antibiotics (stimulation/inhibition) on the ability of microorganisms to form biofilms and persist in the body. It is proposed to determine the sensitivity to antibiotics of 10 isolated pure cultures of microorganisms of the same species, and to give preference to the antibiotic, to which all isolated clones of this type of bacteria are susceptible. The use of an antibiotic selected according to the proposed technique allows sanitizing the focus of purulent inflammation in a short time and reducing the number of high amputations by 2 times.

The study was conducted to identify the prevalence of malformations of the maxillofacial area and oral organs in children with congenital neuropsychiatric disorders and to determine their predictive properties in the formation of acquired dental diseases. The object of the study involved 277 children with neuropsychiatric pathology and 260 children without comorbid pathology. It was established that children with neuropsychiatric pathology had a high percentage of congenital pathology of the maxillofacial area and oral cavity in comparison with the control group. The identified orofacial anomalies can be classified as congenital morphological predictors of dental diseases, as they are well-known and proven risk factors for developing hard dental tissue diseases, periodontal disease, cheilitis, stomatitis, etc.

The aim of the work was the studying of stress changes in the hippocampus microvascular bed in male rats under chronic immobilization and chronic emotionally painful stresses. Lesions were found in the hippocampus CA1 and CA3 fields accompanied by dystrophic changes in neurons and their death. Simultaneously, the development of microvascular involvement (mainly, capillaries and a postcapillary-venular part) with destruction of the blood-brain barrier structures is revealed. The article discusses the role of stress as one of the trigger factors in the aging of the hippocampus structures and its damage in Alzheimer's disease. The data obtained give reason to consider the problems of age-related neurodegenerative lesions, changes in cerebral microcirculation, the state of the blood-brain barrier and the participation of stress-related mechanisms in them as a single complex.