The article presents the results of a study on the assessment of the prevalence of depression and vital exhaustion in patients with stage II hypertensive disease, living on the territory of the Donbass. According to the examination using Beck Depression Inventory of 1,328 patients, depression of more than 20 points was identified in 15 (1.1±0.8%) patients (patients were referred for psychiatrist counseling), and depression of situational or neurotic genesis (10-19 points) - in 216 (16.3±0.3%) patients. All patients with situational depression demonstrated a moderate vital exhaustion according to Maastricht Questionnaire. A strong linear positive correlation between the levels of depression, vital exhaustion and also the indices of systolic and diastolic blood pressure was revealed.

The article presents the results of studying the effectiveness of differentiated programs for restorative education for patients after ischemic stroke taking into account the lateralization profile (when the lesion is localized in the dominant and not dominant hemisphere of the brain). Differentiated rehabilitation programs for patients after ischemic stroke with the use of automated recovery methods (in this case, software and hardware complex of computer vision "Visual Medicine") allows to exert an accented influence on certain parameters of motor functions, taking into account the level organization of movements and the initial degree of severity of the disorder . The practical significance of the results of the study includes a need for simultaneous activation of three levels of movement organization (locomotor, voluntary, and automated) in the rehabilitation training with the consequent transformation of certain voluntary movements and actions into automated motor programs that form the basis of self-service skills.

The features of personal response to illness in the course of managing temporal and mandibular joint (TMJ) pathology in 52 (27 men and 25 women) aged from 19 up to 63 years, accompanied by dysplasia are studied. The features of patients’ psychological adaptation to illness and in carrying out dental rehabilitation are studied taking into account the severity of temporal and mandibular joint pathology by assessing the syndrome of psycho- sensory anatomical-functional disadaptation (SPSAFD). It has been established that with clinical picture of TMJ pathology in patients getting worse the value of SPSAFD integrated indicator has increased. The reliable differences in personal response to illness in favorable outcome of managing TMJ pathology have been revealed. It has been concluded that rational use of the SPSAFD analysis technique in stomatologic arthrology will enable to correct the pathology and will be one of directions in improving patients’ satisfaction with the quality ofdental help.

Pathological health of a newborn or a child in the early neonatal period is a manifestation of the complex effects of various factors during pregnancy and childbirth, which require the detailed analysis and are of great scientific and clinical interest. To assess the risk factors and dynamics of clinical manifestations of the consequences of perinatal damage to the nervous system, the somatic health of women, reproductive and gynecological history, features of the course and complications of pregnancy and childbirth were evaluated on the scale of the optimal course of pregnancy and the scale of the optimal course of childbirth. On the basis of this, it is important to build the most sensitive and reliably significant relationships of markers and indices of pregnancy and childbirth in women with different degrees of severity of the consequences of central nervous system perinatal lesions in children.

134 children with functional dyspepsia (FD) at the age from 5 to 15 years were examined. The presence of connective tissue dysplasia and dysembryogenesis stigmata was revealed in the phenotype of 88.0 % of children with FD, 6 or more stigmas were observed in 31.3 % of patients, most often in ulcer-like dyspepsia. The average number of stigmas in a child with FD was 5.0 ± 0.3. In children with FD hyperinsulinemia was observed, the most significant in ulcer-like and dysmotility-like dyspepsias. The level of cortisol in the blood serum in children with FD was within the lower limit of normal, while hypercortisolemia was typical for patients with ulcer-like dyspepsia. In children with multiple stigmas of connective tissue dysplasia and dysembryogenesis, a low content of insulin and cortisol in the blood serum was detected. Probably, this may cause a more severe course of FD in children of this group with a high risk of its transformation into the chronic pathology of the gastroduodenal area.

Community-acquired pneumonia keeps a dominate position in the structure of infectious mortality factors in the world. Immune and metabolic disorders are studied before and after standard medical therapy in patients with community-acquired pneumonia. The patients included in the research had laboratory criteria which indicated presence of immune inflammation, oxidative stress, endothelial dysfunction, and activation of lipid peroxidation. Standard treatment does not normalize the majority of modified parameters of immune and metabolic status that set conditions for seeking methods of disorders correction by the use of various drug combinations of immunomodulatory and antioxidant action in complex pharmacotherapy.

The improvement of the higher medical education system requires searching for new methods of academic and educational work. These methods are aimed to encourage healthy lifestyle and develop skills of conducting cultural- educational work on primary prevention of some socially significant diseases. Organizational and methodical particularities of training in future healthy lifestyle have been analyzed in the article. These particularities determine many important factors for successful developing health-saving mentality and behavior. The teaching principles of developing healthy lifestyle are close to principles of health-saving pedagogical science. There is a need for active and group methods of teaching healthy lifestyle and conducting primary prevention of diseases. The methods of this study are situational, logical and statistical.

We studied the morphological state of liver tissue and morphometrical parameters of hepatocytes in Wistar male rats subjected to acute foot-shock stress and Selank influence on liver condition. The peptide was administered by intraperitoneal injections in doses 100, 300 and 1,000 µg/kg 15 min before stress exposure. We revealed that acute foot-shock stress resulted in developing mild hepatocytic degeneration which was more pronounced in centrilobular regions, inflammatory infiltration which was more developed in peripheral parts of liver lobules, growth of the mean areas of hepatocyte, nucleus, and cytoplasm without changes of NCR. Selank showed an ameliorative effect on stress-induced alterations. The 100 µg/kg peptide administration influenced the dystrophic changes greater, 300 µg/kg peptide administration had a greater impact on the inflammatory infiltration, 1,000 µg/kg Selank application showed an average effect on the parameters above-mentioned. The peptide administration didn’t influence the mean area of hepatocyte; however it led to further growth of the mean area of nucleus in doses 100 and 1,000 µg/kg.

The goal of the research is to study the effectiveness of transcranial direct current stimulation (tDCS) for correcting stress-induced hormonal and cytokine disturbances in rats with low stress sustainability. There were 3 groups of rats: group 1 - intact, group 2 (without tDCS) and group 3 (with tDCS) - with low stress sustainability. Two forced swimming tests were carried out on days 1 and 7, on the 8th day - orthostatic stress with subsequent collection of blood. Orthostatic stress in group 2 was accompanied by growth: adrenaline by 88.9%, ACTH 10.5 times, corticosterone by 70.1%, IL-1β by 178.2%, IL-6 by 6.7 times, IL- 10 by 37.1%, in comparison with the group 1. In group 3, the duration of swimming of rats increased by 47.7%. After orthostatic stress, a decrease in content was revealed: adrenaline 1.4 times, ACTH 8.2 times, corticosterone 1.4 times, IL-1β 1.5 times, IL-6 2.2 times, IL-10 in 1.2 times in relation to group number 2.

To reveal the intraorganic arterial anastomoses we studied arterial lobar architectonics and the topography of true hepatic interlobar borders. 23 samples of cadaveric liver were studied with the use of preparating technique, separate injecting colouring solutions, microfocus angiography, and transparenchymal sections. When the arterial bed of the liver was injected with colouring solutions or radiocontrast agents, in 21 cases the agents were visualized only within the injected lobe. In 2 observations, an extraorgan arterial anastomosis was detected between the branches of the hepatic artery in the gates of the liver. The investigation revealed that the anatomical and surgical concepts of the inter-lobar hepatic border do not coincide according to the arterial sign; macroscopically visible inter-lobar intraorganic arterial anastomoses are normally absent, which indicates the relative isolation of hepatic lobes.

A clinical and experimental study was conducted to identify morphological changes in the spiral organ of animals and the possibility of exposure to the morphological substrate of the disease in persons with hearing loss due to vibroacoustic effects. The experiment involved 34 white mongrel rats. A clinical part included an audiological examination of 127 railroad employees. In the experiment, a group of intact animals, a group of rats was exposed to noise and vibration against the background of immobilization without treatment. The second group of rats was exposed to the same vibration and noise, but it got simultaneous treatment with the drug Sildenafil having the vascular effect. And the third group of rats with hearing loss received the therapeutic drug with a delay. The morphological study of the animals’ temporal cochlea proved the degenerative changes in the spiral organ, the signs of cell apoptosis of the inner ear and spiral ganglion. Drug therapy with Sildenafil was more effective when used simultaneously.

The combined use of Perftoran and antibiotic drugs Lincomycin, Tsiprolet, and Cefotaxime on the level of their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was produced “in vitro” in order to study the synergistic effect. The method of agar dilution with the collection strains Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris ATCC 4636, and Candida albicans NCTC 2625 was used. It was found, that Perftoran does not have an antibacterial effect with respect to the test strains. The combined introduction of Perftoran and antibiotic drugs into a nutrient medium reduces MIC and MBC. This effect is the highest when combining Perftoran with Cefotaxime - MIC decreased 8-32 times, MBC - 4-64 times. This effect was also observed in relation to individual cultures but not more than 2-4 times. The observed effect is due to the entry of facultative anaerobes into the vegetative phase, which reduces their resistance to the action of antibiotics.