Reduction of mortality in patients with acute coronary pathology continues to be the leading task of cardiology. Heart rate is one of the important criteria for the adequacy of ongoing treatment and rehabilitation of patients, since the achievement of target values is accompanied by a decrease in the relative risk of cardiac death and the risk of sudden death. The study included 86 patients with unstable angina and 111 patients with acute myocardial infarction at the age of 40-65 years, whose functional state was evaluated by the Omega-M software-hardware complex according to the integrated parameters on the 3rd, 8th and 14th days. The correlation of heart rate with the parameter of vegetative regulation was discovered, that can be used as a prognostic criterion for achievement of target heart rate in patients with acute coronary pathology at stages of hospital rehabilitation.

432 patients (213 men (49.3%) and 219 women (50.7%)) with vulgar psoriasis were examined. Depending on the size of the PASI index, the patients were divided into two groups: with a limited form (PASI - 9.6±0.01, n = 60) and with a common form of the disease (PASI - 49.53±0.46, n = 372). 312 patients with a common form of psoriasis had signs of metabolic syndrome (MS) and made up the main group, another part of patients (n = 60) with a common form of the disease, without signs of MS -comparison group. Anthropometric examination and determination of leptin level in blood were carried out in the examined patients. A statistically significant relationship between the prevalence of the skin process, the level of blood leptin and the presence of MS is shown, which indicates the pathogenetic role of metabolic disturbances in psoriasis.

In order to determine the role of products of lipid, peptides and nitro compounds oxidative metabolism in damages of vascular endothelium due to arterial hypertension (AH), 58 patients with AH aged 40-74 were examined by methods of endothelium dependent vasodilatation, enzyme immunoassay, spectrophotometry, determination of serum nitric oxide activity with Griss reagent. It was established that the severity of endothelial dysfunction against the background of hypertension depends on the intensity of oxidative reactions: at an early stage, intense oxidation of lipids takes place; Later, phase changes in the content of the nitrites and nitrotyrosine level are added. The progression of endothelial lesions in the initial stages is associated with the level of total oxidative activity, and at later stages with the concentration of oxidation products of peptides, which is of great diagnostic and prognostic value for evaluating the severity of endothelial damage as a target organ in hypertension.

The article presents the results of surgical treatment of bleeding from varicose veins of the esophagus and stomach in patients with decompensated liver cirrhosis. The study included 55 patients. The median age was 50.5±12.7 years. The vast majority of patients had clinical signs of severe liver failure in accordance with the criteria Child-Turcotte-Pugh (class B - 7, class C - 48 patients). Two groups were distinguished among the patients. In the first group, patients underwent only endoscopic ligation. The second used a combination treatment: laparoscopic gastric and esophageal devascularization with pre-or intraoperative endoscopic ligation of esophageal veins. The obtained results indicated an increase in the survival rate of patients in the second group.

The analysis of 28,925 medical cases in the maxillofacial surgery and dentistry inpatient departments of medical-prophylactic institutions of St-Petersburg, Yekaterinburg and Rostov-on-Don revealed that patients suffering from odontogenic subcutaneous granuloma faciale (OSGF) amounts to 0.07-0.42%. It has been noted that patients with OSGF often first seek not only dental help but also consult physicians of related specialties (general practitioners, internists, dermatologists, general surgeons). It is shown that the defects of detecting OSGF in polyclinics occur in 87.04% of cases and the disease is initially treated as acute exacerbation of chronic odontogenic osteomyelitis of jaws, festering atheroma, or abscess forming the boil.

The article presents the results the study of cytokine profile, antimicrobial peptides (α-defensins), as well as the indices of cellular immunity in patients with seasonal allergic rhinitis in the stage of exacerbation. It is shown that the immune status of patients is characterized by an increase in the relative amount of CD3-CD19+ lymphocytes and a decrease in CD3 + CD8 + cells, activation of humoral immunity and an increase in the concentration of Th2 cytokine regulators of the immune response (IL-4 and IL-10) in nasal secretion and serum. This was combined with a decrease in the functional activity of Th1-lymphocytes, regulators of the cellular immune response, increased production of pro-inflammatory cytokines (IL-1β, IL-8) and antimicrobial peptides-α-defensins (HNP1-3), promoting degranulation of mast cells and secretion of mediators supporting allergic inflammation.

Congenital dyskeratosis (syndrome of Zinsser-Engman-Cole) belongs to the group of rare genetic syndromes, which are manifested by skin and mucous membranes abnormalities, bone marrow insufficiency and a tendency to develop malignant diseases. This pathology is extremely rare, up to the present time there are no exact data, approximately the prevalence is 1: 1 000 000 per year, with predominantly male patients (in the ratio of 3: 1). In total, according to the literature, about 60 patients with this pathology are described. The article describes the clinical case of congenital dyskeratosis in a child aged 1 year 10 months, its main clinical manifestations, features of diagnosis and treatment.

By questioning 140 patients who were treated as outpatients in various municipal dental clinics, the features of using non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief were studied. The assassment of the pain syndrome nature and the effectiveness of pain relief was carried out in patients in the postoperative period after typical dental operations, as well as in non-surgical situations. It was found that more often NSAIDs are taken by women and persons of older age groups due to the peculiarities of the pain syndrome in premenstrual period and the presence of comorbid pathology, respectively. The most used non-steroidal anti-inflammatory drugs for today are Ketorolac (Ketorol, Ketanov) and Ibuprofen (Nurofen, MIG, Next, Sedalgin), which have moderate selectivity for cyclooxygenase - 1, and which were used by 64.2% of the surveyed patients. Bad pain within 24 hours following the treatment after using these NSAIDs persisted in 2.2% of patients.

It was established in an experiment on 216 white male rats of 3 age groups (immature, mature and elderly) that excessive consumption of refined palm oil (30 g/kg/day) is accompanied by an increase in the content of glucose and lactate in blood serum, as well as a decrease in the content of glycogen in the homogenate of liver tissue. The severity of changes depended on the duration of the experiment and the rats’ age. In mature and elderly rats, these changes developed more slowly as compared to immature rats, but progress more rapidly. The intragastric administration of Garcinia Cambogia extract (0.25 mg/kg/day) increases the glucose and lactate content in blood serum and decreases glycogen content in the homogenate of liver tissue, compared with control group. The most effective use of Garcinia Cambogia extract was noted in mature rats.

Betahistine and Piracetam are routine drugs in neurological practice, which are used to correct cerebral circulation disorders. The clinical efficacy of these drugs can be caused not only by neuro-, but also by endotheliotropic action. In this review, the main information on the potential mechanisms for the implementation of vasoprotection, including metabolic, NO-ergic, anti-inflammatory and other components of the action are discussed. Betahistine as histamine receptors type 3 antagonist and histamine receptors type 1 and 2 agonist has a positive effect on cerebral and systemic hemodynamics, and due to anorexigenic action and the ability to stimulate lipolysis can ameliorate dyslipidemia. Piracetam, along with a nootropic effect, contributes to the correction of mitochondrial dysfunction, increases the fluidity of membranes and has antiplatelet properties. Both drugs suppress the synthesis of pro-inflammatory cytokines and increase the expression of endothelial NO synthase.

Changes in the level and variant of portal vein formation can cause difficulties during diagnostic and surgical procedures. The cadaveric material of adults and archival data of the multidetector row spiral CT of the abdomen were studied and analyzed to determine the variant anatomy of the roots and inflows of the portal vein, its morphometric characteristics, level, formation and its application value in surgery. The portal vein was predominantly formed at the level of the L2 vertebra. In 72.3% of cases the inferior mesenteric merged with the splenic vein. The incidence of confluence of inferior mesenteric vein with superior mesenteric vein was found in 22.3% of cases. Confluence of three veins was revealed in 4.7% of cases. Also there was 1 case of forming the portal vein due to the superior mesenteric, inferior mesenteric, splenic and left colic veins (0.7%). The obtained results can be used for revealing and interpreting topographic and anatomical variations at the preoperative stage and are of great practical importance in the surgery of the upper floor of the peritoneal cavity.

Studies of the pathology of the brain in experimental ischemia necessitate adequate methods of assessing the neurological deficit that occurs in laboratory animals, including sensory and behavioral disorders. The purpose of the research was a comparative study of motor and behavioral disorders in rats with partial and incomplete experimental cerebral ischemia. To avoid high mortality of animals with subtotal cerebral ischemia, the author's model of a stepwise (with a break of 7 days) dressing of common carotid arteries was used for simultaneous bandaging of common carotid arteries.The study of the state of sensomotor and motor functions was carried out in the "open field" test, "muscle strength" test, "swimming test". It was found that rats after experimental cerebral ischemia had less muscle strength, were less resistant to hypoxia, and showed less motor and emotional activity. In animals with incomplete cerebral ischemia, more pronounced sensomotor and behavioral disorders were observed as compared to rats with the modeled partial cerebral ischemia and, especially, as compared to control animals.

The main aim of the research is to study the system organization of the dog’s humerus. 78 humeral bones of not purebred dogs (D=R) were studied using osteometry methods. The data obtained were normalized by the value of the transverse diameter of the diaphysis. The data analysis was performed using the principal components method with the rotation of Equamax normalized taking into account the lateralization of bones. As a result, it was found, that the basis of the humerus systemic organization is formed of structures, responsible for taking the animal's body weight. The revealed latent morphofunctional asymmetry of the dog's shoulder bone systemic organization is manifested on the right bone - by high values of factor loads on the anatomical structures, which provides flexion/extension in the joints; for the left shoulder bone - on the structures providing rotations.

Genital prolapse is the weakening or loss of support of pelvic organs, accompanied by their descent or prolapse. There are many etiological reasons for developing this nosology. A form of the small pelvis may play a role in the development of genital prolapse. The study was carried out on 74 preparations of women’s bone pelvis, 30 multidetector row spiral CT of small pelvis of patients with genital prolapse of III - IV degree. Standard and non-standard pelvimetric indices are estimated, on the basis of which a number of indices have been calculated, which make it possible to evaluate the shape of pelvis. According to the results obtained, in the anthropometric study of pelvic bone preparations, the most common forms were mesopelic, medium, uniform, harmonious and round forms of the pelvis. In this case, the cylindrical shape of the cavity of the small pelvis was most often encountered. According to the multidetector row spiral CT data, in women with genital prolapse, platypelic, low, broadened, broad and transversely oval bone pelvis forms were most common. The pelvis of women, suffering from genital prolapse, mainly had a dilating downward form of the small pelvis cavity.

The advantages of isolating the analyzed compound from aboveground and underground parts of medicinal plants with a mixture of organic solvents acetonitrile-dichloroethane-ethyl acetate (6:2:2 by volume) are substantiated by double infusion with the duration of each infusion stage of 30 minutes and the mass ratio of the isolating agent to the biomatrix of 4:1. To purify 2-dimethylamino-1.3-bis-(phenylsulphonylthio) propane recovered from plant biomatrices, macrocolumnic adsorption chromatography on a 40/63 μ silica gel column and successive elution with hexane and a solvent system of diethyl ether-hexane (8:2 by volume) were used. A procedure was developed for the determination of 2-dimethylamino-1.3-bis (phenylsulphonylthio) propane in medicinal plant raw materials using the GC-MS method after preliminary thermal destruction of the test compound. The detection limit of 2-dimethylamino-1.3-bis-(phenylsulphonylthio) propane is 1.0∙10^-4 g in 100 g of biomaterial.

The genus Genista L. of Fabaceae family includes about 75 species distributed in Europe, North Africa and Western Asia. In Russia 4 species grow, the most common is Genista tinctoria L. This species is widely used in traditional medicine as a choleretic and diuretic, for the treatment of thyroid diseases, in oncology and dermatocosmetology. Nevertheless, there is no approved pharmacopeial article on the medicinal plant raw materials. The ability to use a new type in scientific medicine makes it necessary to study the morphological and anatomical structure of the Genista tinctoria. The result of the research revealed the diagnostic features that allow to reliably identify medicinal plant material, and can be used in the development of regulatory documents for «External features» and «Microscopic features». Morphological and anatomical characteristics of leaves of Genista tinctoria were studied for the first time.