Pharmacological correction of immunometabolic disorders in infertility of tubal peritoneal genesis against the background of chronic infections and inflammatory process of the reproductive sphere

Objective. To develop the methods for pharmacological correction of immunometabolic disorders in tubal peritoneal infertility against the background of chronic infections and inflammatory process of the reproductive system. 

Materials and methods. 96 women were under observation with a confirmed diagnosis of secondary infertility of tubal peritoneal genesis against the background of chronic infections and inflammatory process of bacterial-viral etiology in remission. The parameters of the immune status, the intensity of lipid peroxidation processes and the state of the antioxidant system were revealed in the peripheral blood and cervical-vaginal washout. All women were equally divided into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BFT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). The 2nd-4th group, in addition to BFT, respectively received Hepone, Cycloferon or Lavomax within 30 days. 

Results. Within 24 hours following the diagnostic and treatment laparoscopy the endothelial dysfunction, «oxidative stress», and activation of lipid peroxidation processes were established at the systemic and local levels. BFT was not effective enough, after Hepon was administered 86.7% of laboratory parameters remained impaired, and the use of Cycloferon reduced their number to 71.1%. The most effective was the inclusion of Lavomax in BFT, since 60% of the laboratory parameters studied remained unchanged. 

Conclusion. Administration of Hepon, Cycloferon, and especially Lavomax while conducting BFT for tubal peritoneal infertility has shown their high efficiency in the correction of impaired parameters of the immune and metabolic status at the systemic and local levels.