The development of new methods of analyzing combined tablets for arterial hypertension

Abstract

A new original drug formulation for managing hypertension - combined tablets codenamed “Bisopamid” was presented. The combination of active pharmaceutical ingredients of different pharmacological groups expands the mechanisms of antihypertensive action, reduces the incidence of side effects, prevents organ damage, increases compliance of patients to treatment.The methods of identification and quantitative analysis of new antihypertensive multicomponent tablets “Bisopamid” by HPLC were developed for quality control of the proposed formulation. The advantage of the proposed method is the possibility of simultaneous identification and quantification of the content of the three active pharmaceutical ingredients in a combined preparation (bisoprolol, lisinopril, indapamide). The techniques were used for analyzing the experimental samples of the drug. The results are well reproducible and credible. The developed techniques were introduced in the document ‘Guidelines for quality control of a medicinal product”.