Morphological changes in the neural and vascular structures of the hippocampus during chronic immobilization and emotionally painful stress in the experiment and their analysis in connection with the aging of brain and pathogenesis of Alzheimer's disease

The aim of the work was the studying of stress changes in the hippocampus microvascular bed in male rats under chronic immobilization and chronic emotionally painful stresses. Lesions were found in the hippocampus CA1 and CA3 fields accompanied by dystrophic changes in neurons and their death. Simultaneously, the development of microvascular involvement (mainly, capillaries and a postcapillary-venular part) with destruction of the blood-brain barrier structures is revealed. The article discusses the role of stress as one of the trigger factors in the aging of the hippocampus structures and its damage in Alzheimer's disease. The data obtained give reason to consider the problems of age-related neurodegenerative lesions, changes in cerebral microcirculation, the state of the blood-brain barrier and the participation of stress-related mechanisms in them as a single complex.

стресс, гиппокамп, болезнь Альцгеймера, старение, гематоэнцефалический барьер, микрососудистое русло, повреждение нейронов, stress, hippocampus, Alzheimer's disease, aging, blood-brain barrier, microvascular bed, neuronal damage

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