kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2018-4/15kurskvest-537Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИMEDICOBIOLOGICAL SCIENCESМорфологические изменения нейральных и сосудистых структур гиппокампа при хроническом иммобилизационном и эмоционально-болевом стрессе в эксперименте и их анализ в связи со старением головного мозга и патогенезом болезни АльцгеймераMorphological changes in the neural and vascular structures of the hippocampus during chronic immobilization and emotionally painful stress in the experiment and their analysis in connection with the aging of brain and pathogenesis of Alzheimer's diseaseДолжиковА. А.DolzhikovA. A.noemail@neicon.ruБобынцевИ. И.BobyntsevI. I.noemail@neicon.ruБелыхА. Е.BelykhA. E.noemail@neicon.ruДолжиковаИ. Н.DolzhikovaI. N.noemail@neicon.ruБелгородский государственный национальный исследовательский университетРоссияBelgorod State National Research UniversityRussian FederationКурский государственный медицинский университетРоссияKursk State Medical UniversityRussian Federation2018201220180495103Copyright © Должиков А.А., Бобынцев И.И., Белых А.Е., Должикова И.Н., 20182018Должиков А.А., Бобынцев И.И., Белых А.Е., Должикова И.Н.Dolzhikov A.A., Bobyntsev I.I., Belykh A.E., Dolzhikova I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/537

Целью работы являлось изучение изменений микрососудистого русла гиппокампа при стрессе у крыс-самцов в условиях хронического иммобилизационного стресса и хронического эмоционально-болевого стресса. Обнаружены поражения в полях СА1 и СА3 гиппокампа с дистрофическими изменениями нейронов, их гибелью. Одновременно показано развитие поражения микрососудов, в основном капилляров и посткапиллярно-венулярного звена с разрушением структур гематоэнцефалического барьера. В статье обсуждается роль стресса как одного из триггерных факторов в старении структур гиппокампа и его поражении при болезни Альцгеймера. Полученные данные дают основания рассматривать в едином комплексе проблемы связанных или не связанных с возрастом нейродегенеративных поражений, изменений церебральной микроциркуляции, состояния гематоэнцефалического барьера и участия в них стресс-обусловленных механизмов.

The aim of the work was the studying of stress changes in the hippocampus microvascular bed in male rats under chronic immobilization and chronic emotionally painful stresses. Lesions were found in the hippocampus CA1 and CA3 fields accompanied by dystrophic changes in neurons and their death. Simultaneously, the development of microvascular involvement (mainly, capillaries and a postcapillary-venular part) with destruction of the blood-brain barrier structures is revealed. The article discusses the role of stress as one of the trigger factors in the aging of the hippocampus structures and its damage in Alzheimer's disease. The data obtained give reason to consider the problems of age-related neurodegenerative lesions, changes in cerebral microcirculation, the state of the blood-brain barrier and the participation of stress-related mechanisms in them as a single complex.

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The authors declare that there are no conflicts of interest present.