Determination of ceftriaxone in biological material
https://doi.org/10.21626/vestnik/2018-1/19
Abstract
The possibility of ceftriaxone determination by IR spectroscopy in biological material is studied, as well as the possibility of proving the authenticity of a functional sample of the antibiotic analyzed in comparison with a standard sample. The studies were carried out on the prototyping mixtures of the analyte with the tissue of the cadaveric liver, which had no signs of a putrefactive change. The IR spectra of the functional and reference samples were found to coincide with characteristic absorption bands that prove the possibility of using a functional sample for further research with a view to economic benefit. The possibility of applying IR spectroscopy for the identification of ceftriaxone in extracts from biological material is substantiated. The practice of isolation and purification of ceftriaxone extracted from biological material has been applied in practice.
About the Authors
A. A. Bezyazychnaya
Kursk State Medical University
Russian Federation
Russian Federation
V. K. Shormanov
Kursk State Medical University
Russian Federation
Russian Federation
L. E. Siplivaya
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Bezyazychnaya A.A., Shormanov V.K., Siplivaya L.E. Determination of ceftriaxone in biological material. Kursk Scientific and Practical Bulletin "Man and His Health". 2018;(1):128-132. (In Russ.) https://doi.org/10.21626/vestnik/2018-1/19
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