Antibacterial effects of herbal extracts and their combinations with antibiotics in relation to extensively antibiotic-resistant microorganisms
https://doi.org/10.21626/vestnik/2018-1/12
Abstract
Minimal inhibitory concentrations (MICs) of 17 officinal aqueous medicinal herbal extracts in regard to antibiotic-sensitive and extensively antibiotic-resistant P. aeruginosa and A. baumannii isolates were determined. The expressed antibacterial activity (MIC < 1 mg/mL) was found for aqueous cowberry ( Vaccinium vitis-idaea ), eucalyptus ( Eucalyptus viminalis ), oak ( Quercus robur ), and bearberry ( Arctostaphylos uva-ursi ) extracts. Aqueous herbal extracts did not influence significantly the antibacterial activity of aminoglycosides, carbapenems and fluoroquinolones during their combined action on a microbial cell. A universal dose-dependent antagonistic effect of herbal extracts on the colistin microbiological efficacy in relation to A. baumannii and P. aeruginosa was revealed. A synergistic antibacterial effect (SFIC 0.25-0.50) of the combination of aqueous eucalyptus extract with the ceftazidime against 29.2% of OXA-carbapenemase producing A. baumannii strains was detected.
About the Authors
D. V. Tapalski
Gomel State Medical University
Russian Federation
Russian Federation
F. D. Tapalski
Vitebsk State Medical University
Russian Federation
Russian Federation
References
1. Сухорукова М.В., Эйдельштейн М.В., Склеенова Е.Ю., Иванчик Н.В., Шек Е.А., Дехнич А.В., Козлов Р.С., исследовательская группа «МАРАФОН». Антибиотикорезистентность нозокомиальных штаммов Acinetobacter spp. в стационарах России: результаты многоцентрового эпидемиологического исследования «МАРАФОН» 2013-2014 // Клиническая микробиология и антимикробная химиотерапия. - 2017. - Т. 19, № 1. - С. 42-48. [Sukhorukova M.V., Edelstein M.V., Skleenova E.Yu., Ivanchik N.V., Shek E.A., Dekhnich A.V., Kozlov R.S., «MARATHON» study group. Antimicrobial resistance of nosocomial Acinetobacter spp. isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2017; 19 (1): 42-48. (in Russ.)].
2. Тапальский Д.В., Осипов В.А., Жаворонок С.В. Карбапенемазы грамотрицательных бактерий: распространение и методы детекции // Медицинский журнал. - 2012. - № 2. - С. 10-15. [Tapalski D.V., Osipov V.A., Zhavoronok S.V. Сarbapenemases of gram-negative pathogens: spread and methods of detection. Meditsinskiy zhurnal. 2012; (2): 10-15. (in Russ.)].
3. Эйдельштейн М.В., Сухорукова М.В., Склеенова Е.Ю., Иванчик Н.В., Микотина А.В., Шек Е.А. Дехнич А.В., Азизов И.С., Козлов Р.С. Антибиотикорезистентность нозокомиальных штаммов Pseudomonas aeruginosa в стационарах России: результаты многоцентрового эпидемиологического исследования «МАРАФОН» 2013-2014 // Клиническая микробиология и антимикробная химиотерапия. - 2017. - Т. 19, № 1. - С. 37-41. [Edelstein M.V., Sukhorukova M.V., Skleenova E.Yu., Ivanchik N.V., Mikotina A.V., Sheck E.A., Dekhnich A.V., Azizov I.S., Kozlov R.S. «MARATHON» study group. Antimicrobial resistance of nosocomial Pseudomonas aeruginosa isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2017; 19 (1): 37-41 (in Russ.)].
4. Abdallah E.M. Plants: an alternative source for antimicrobials // Journal of Applied Pharmaceutical Science. - 2011. - Vol. 1, N 6. - P. 16-20.
5. Adwan G., Abu-Shanab B., Adwan K. Antibacterial activities of some plant extracts alone and in combination with different antimicrobials against multidrug-resistant Pseudomonas aeruginosa strains // Asian Pacific Journal of Tropical Medicine. - 2010. - Vol. 3, N 4. - P. 266-269. - DOI: 10.1016/S1995-7645(10)60064-8.
6. Das K., Tiwari R.K.S., Shrivastava D.K. Techniques for evaluation of medicinal plant products as antimicrobial agent: current methods and future trends // Journal of Medicinal Plants Research. - 2010. - Vol. 4, N 2 - P. 104-111. - DOI: 10.5897/JMPR09.03.
7. Djeussi D.E., Noumedem J.A., Seukep J.A., Fankam A.G., Voukeng I.K., Tankeo S.B., Nkuete A.H., Kuete V. Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria // BMC Complementary and Alternative Medicine. - 2013. - Vol. 13. - P. 164. - DOI: 10.1186/1472-6882-13-164.
8. Guclu E., Genc H., Zengin M., Karabay O. Antibacterial activity of Lythrum salicaria against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa // Annual Research and Review in Biology - 2014. - Vol. 4, N 7. - P. 1099-1105. - DOI: 10.9734/ARRB/2014/7357.
9. Heidary M., Hashemi A., Goudarzi H., Khoshnood S., Roshani M., Azimi H., Goudarzi M. The antibacterial activity of Iranian plants extracts against metallo betalactamase producing Pseudomonas aeruginosa strains // Journal of Paramedical Sciences. - 2016. - Vol. 7, N 1. - P. 13-19. - DOI: 10.22037/jps.v7i1.11203.
10. Humadi S.S., Istudor V. Lythrum salicaria (purple loosestrıfe). Medicinal use, extraction and identification of its total phenolic compounds // FARMACIA. - 2009. - Vol. 57, N 2. - P. 192-200.
11. Magiorakos A.P., Srinivasan A., Carey R.B., Carmeli Y., Falagas M.E., Giske C.G., Harbarth S., Hindler J.F., Kahlmeter G., Olsson-Liljequist B., Paterson D.L., Rice L.B., Stelling J., Struelens M.J., Vatopoulos A., Weber J.T., Monnet D.L. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance // Clinical Microbiology and Infection. - 2012. - Vol. 18, N 3. - P. 268-281. - DOI: 10.1111/j.1469-0691.2011.03570.x.
12. Miyasaki Y., Nichols W.S., Morgan M.A., Kwan J.A., Van Benschoten M.M., Kittell P.E., Hardy W.D. Screening of herbal extracts against multi-drug resistant Acinetobacter baumannii // Phytotherapy Research. - 2010. - Vol. 24, N 8. - P. 1202-1206. - DOI: 10.1002/ptr.3113.
13. Miyasaki Y., Rabenstein J.D., Rhea J., Crouch M.-L., Mocek U.M., Kittell P.E., Morgan M.A., Nichols W.S., Van Benschoten M. M., Hardy W.D., Liu G.Y. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii // PLoS One. - 2013. - Vol. 8, N 4. - Art. e61594. - DOI: 10.1371/journal.pone.0061594.
14. Reda F.M., El-Zawahry Y.A., Omar A.R. Synergistic effect of combined antibiotic and methanol extract of Eucalyptus camaldulensis leaf against Staphylococcus aureus and Pseudomonas aeruginosa // International Journal of Applied Sciences and Biotechnology. - 2017. - Vol. 5, N 4. - P. 486-497. - DOI: 10.3126/ijasbt.v5i4.18620.
15. Sebei K., Sakouhi F., Herchi W., Khouja M.L., Boukhchina S. Chemical composition and antibacterial activities of seven Eucalyptus species essential oils leaves // Biological Research. - 2015. - Vol. 48, N 1. - P. 7. - DOI: 10.1186/0717-6287-48-7.
16. Srivastava J., Chandra H., Nautiya A.R., Kalra S.J.S. Antimicrobial resistance and plant-derived antimicrobials as an alternative drug line to control infections // 3 Biotech. - 2014. - Vol. 4, N 5 - P. 451-460. - DOI: 10.1007/s13205-013-0180-y.
17. Tegos G., Stermitz F.R., Lomovskaya O., Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials // Antimicrobial Agents and Chemotherapy. - 2002. - Vol. 46, N 10. - P. 3133-3141. - DOI: 10.1128/AAC.46.10.3133-3141.2002.
18. White R.L., Burgess D.S., Manduru M., Bosso J.A. Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test // Antimicrobial Agents and Chemotherapy. - 1996. - Vol. 40, N 8. - P. 1914-1918.
Review
For citations:
Tapalski D.V., Tapalski F.D. Antibacterial effects of herbal extracts and their combinations with antibiotics in relation to extensively antibiotic-resistant microorganisms. Kursk Scientific and Practical Bulletin "Man and His Health". 2018;(1):78-83. (In Russ.) https://doi.org/10.21626/vestnik/2018-1/12
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