Mediators of endothelial dysfunction in premature newborns with respiratory distress syndrome
Abstract
The main mediators of endothelial dysfunction (nitrogen oxide and endothelin-1) in premature newborns with respiratory disorders were researched: I group - 90 infants with congenital pneumonia, II group - 90 infants with respiratory distress syndrome, III group - 90 patients with congenital pneumonia and respiratory distress syndrome. The control group involved 30 ‘conditionally’ healthy premature infants. The lowest level of nitrogen oxide in cord blood was in the group of examined prematures with congenital pneumonia and respiratory distress syndrome (24.0±2.9 microM/l) and respiratory distress syndrome (25.7±5.8microM/l), (р < 0.05). The highest content of endothelin-1 in cord blood was in prematures with congenital pneumonia and respiratory distress syndrome: 4.13±0.69 f Mole/mL and 3.02±0.28 fMole/mL respectively (р < 0.05). On the 7th day of life the level of nitrogen oxide in venous blood increased twice in comparison with that in the cord blood. The level of endothelin-1 in venous blood became less as opposed to cord blood. These findings confirm the presence of long-lasting pulmonary hypertension in premature newborns with pulmonary disease.
About the Authors
L. A. Levchenko
Kursk State Medical University, Kursk
Russian Federation
Russian Federation
T. M. Klimenko
Kharkov Medical Academy of Postgraduate Education, Kharkov, Ukraine
Russian Federation
Russian Federation
I. G. Khmelevskaya
Kursk State Medical University, Kursk
Russian Federation
Russian Federation
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Review
For citations:
Levchenko L.A., Klimenko T.M., Khmelevskaya I.G. Mediators of endothelial dysfunction in premature newborns with respiratory distress syndrome. Kursk Scientific and Practical Bulletin "Man and His Health". 2015;(2):38-42. (In Russ.)
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