Role of the polymorphism (rs55754655) of the enzyme gene of the antioxidant system in the development of chronic pancreatitis
https://doi.org/10.21626/vestnik/2017-4/17
Abstract
An important role in the development of chronic pancreatitis (CP) is given to the action of toxic substances and the disruption of the regulation of pro- and antioxidant defense processes. One of the prooxidant enzymes is aldehyde oxidase (AOX1), which plays a key role in the metabolism of xenobiotics. The aim of the study was to study the relationship between the polymorphism (rs55754655) of the AOX1 gene and the development of CP in the Russian population. Whole blood samples were collected from 241 patients with CP and 132 healthy individuals. Genotyping of the polymorphism (rs55754655) of the AOX1 gene was performed using the PCR method with discrimination of alleles with the help of TaqMan probes. It was found that the carriage of the G allele (OR = 2.49 95% CI 1.27-4.88 p = 0.01) and the A / G genotype was associated with an increased risk of developing CP (OR = 2.8 95% CI 1.32-5.86 p = 0.01). The stratified gender analysis showed that the genotype A / G was associated with the development of CP only in women (OR = 2.57 95% CI 1.09-6.04 p = 0.01). Smokers with A / G genotype have a high risk of developing chronic pancreatitis (OR = 6.47 95% CI 0.82-51.23, p = 0.05).
About the Authors
T. A. Samghina
Kursk State Medical University
Russian Federation
Russian Federation
Y. V. Kanishchev
Kursk State Medical University
Russian Federation
Russian Federation
S. A. Al Isaee Hanan
Kursk State Medical University
Russian Federation
Russian Federation
P. M. Nazarenko
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Samghina T.A., Kanishchev Y.V., Al Isaee Hanan S.A., Nazarenko P.M., Polonikov A.V. Role of the polymorphism (rs55754655) of the enzyme gene of the antioxidant system in the development of chronic pancreatitis. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(4):99-102. (In Russ.) https://doi.org/10.21626/vestnik/2017-4/17
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