The effect of ACTH4-7-PGP peptide (Semax) on the liver structure in rats under acute foot-shock stress
https://doi.org/10.21626/vestnik/2017-3/14
Abstract
The acute foot-shock stress in rats develops a stress reaction, which is confirmed by accidental involution of the thymus and a set of stress-induced changes in the liver parenchyma in the form of the sinusoidal capillary dilation, discomplexation of hepatic beams and the signs of hydropic dystrophy. The intraperitoneal injection of ACTH4-7-PGP (Semax) under foot-shocked stress caused mitigation of the thymus accidental involution, parenchymal structure recovery, reduction in size and severity of hepatic hydropic degeneration, and increase in the number of poly-nucleolus hepatocytes.
Keywords
гепатоциты,
стресс,
аналог АКТГ,
семакс,
печень,
hepatocytes,
stress,
an analogue of ACTH,
semax,
liver
About the Authors
O. M. Shepeleva
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Ivanov
Kursk State Medical University
Russian Federation
Russian Federation
I. I. Bobyntsev
Kursk State Medical University
Russian Federation
Russian Federation
A. A. Kryukov
Kursk State Medical University
Russian Federation
Russian Federation
L. A. Andreeva
Institute of Molecular Genetics of Russian Academy of Sciences
Russian Federation
Russian Federation
N. F. Myasoedov
Institute of Molecular Genetics of Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Shepeleva O.M., Ivanov A.V., Bobyntsev I.I., Kryukov A.A., Andreeva L.A., Myasoedov N.F. The effect of ACTH4-7-PGP peptide (Semax) on the liver structure in rats under acute foot-shock stress. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(3):81-85. (In Russ.) https://doi.org/10.21626/vestnik/2017-3/14
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