Study of interrelations in the maladaptive process in lipid transport system in patients with coronary artery disease
https://doi.org/10.21626/vestnik/2017-2/05
Abstract
We enrolled 54 stable angina patients (class II-III on CCS Angina Grading Scale), aged from 50 to 70 years, and prescribed rosuvastatin 5 mg daily, with the possible increase in the dose to 10 mg to attain the target lipid levels according to Russian National Recommendations. After 6 and 12 months of observation the carotid intima-media thickness (CIMT) was evaluated. Against the background of the achieved total cholesterol (TC) target levels (< 4 mmol/l) and low density lipoprotein cholesterol (LDL-C) target levels (< 1.8 mmol/l) we noted a significant reduction in the maximum CIMT in the groups of patients who achieved target lipid values both at 5 and 10 mg dose, in the latter group this effect was increasing from 6 till 12 months of observation. The decrease in the mean CIMT became evident after 6 months of observation in patients who achieved target lipid levels at 5 mg dose, and after 12 months in patients at 10 mg dose. We found the direct correlation between LDL-C levels and maximum CIMT after 6 months of follow-up, and also between baseline left CIMT and LDL-C levels after 12 months of treatment.
About the Authors
S. I. Kononov
Kursk State Medical University
Russian Federation
Russian Federation
G. S. Mal
Kursk State Medical University
Russian Federation
Russian Federation
L. A. Ukolova
Kursk City Clinical Emergency Hospital
Russian Federation
Russian Federation
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Review
For citations:
Kononov S.I., Mal G.S., Ukolova L.A. Study of interrelations in the maladaptive process in lipid transport system in patients with coronary artery disease. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(2):29-35. (In Russ.) https://doi.org/10.21626/vestnik/2017-2/05
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