Pharmacological potential of lipopolysaccharide Biosynthesis inhibitors in disrupting the pathogenesis of aggressive periodontitis
EDN: WLQXYU
Abstract
Objective - to evaluate the pharmacological potential of inhibitors of lipopolysaccharide biosynthesis in interrupting the pathogenesis of aggressive periodontitis.
Materials and methods. The study included 60 patients diagnosed with aggressive periodontitis. The patients were randomized into two groups: the main group (n=30) received therapy with lipopolysaccharide biosynthesis inhibitors, while the control group (n=30) received standard treatment consisting of occupational hygiene and anti-inflammatory measures.
Results. The study of the effectiveness of lipopolysaccharide biosynthesis inhibitors in the treatment of aggressive periodontitis showed significant changes in inflammatory and microbiological parameters, as well as in the structure of periodontal tissues.
Conclusion. Inhibitors of lipopolysaccharide biosynthesis have shown a pronounced pharmacological effect in the treatment of aggressive periodontitis, including reduction of bacterial load, suppression of inflammation, improvement of periodontal tissue and regeneration of bone structure.
About the Authors
Naida B. Khanmurzaeva
Dagestan State Medical University (DSMU)
Russian Federation
Russian Federation
Gasan M.-A. Budaichiev
Dagestan State Medical University (DSMU)
Russian Federation
Russian Federation
Saida B. Khanmurzaeva
Dagestan State Medical University (DSMU)
Russian Federation
Russian Federation
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Review
For citations:
Khanmurzaeva N.B., Budaichiev G.M., Khanmurzaeva S.B. Pharmacological potential of lipopolysaccharide Biosynthesis inhibitors in disrupting the pathogenesis of aggressive periodontitis. Humans and their health. 2025;28(4):107-112. (In Russ.) EDN: WLQXYU
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