Phenotypical heterogeneity of severe bronchial asthma and the analysis of its treatment in Kursk region
https://doi.org/10.21626/vestnik/2016-3/06
Abstract
The examination of 160 patients with severe asthma who were hospitalized into the pulmonology department of Kursk regional clinical hospital revealed the following phenotypes of the disease according to the GINA, 2016 .: allergic, non-allergic, steroid, asthma in smokers, asthma and obesity, asthma combined with COPD (chiasm syndrome). CHD was diagnosed in 33% of patients with non-allergic asthma and in 65% with the chiasm syndrome accompanied with rhythm disorders as well as in 50% of patients with COPD + BA. Obesity is reported in 77% of female patients with severe asthma and 80.1% of these patients had hypertension. A negative correlation between indicators of FEV1 / FVC ratio, duration of disease, and smoking experience index was established. Infection was the main trigger factor in exacerbations of severe asthma (47.4%). 33.8% of patients were given the inadequate standard asthma outpatient therapy; only 12% of patients with the chiasm syndrome receivedantibiotic therapy in exacerbations of COPD.
About the Authors
S. A. Pribylov
Kursk State Medical University
Russian Federation
Russian Federation
L. V. Samosudova
Kursk State Medical University
Russian Federation
Russian Federation
N. N. Pribylova
Kursk State Medical University
Russian Federation
Russian Federation
O. Yu. Makhova
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Pribylov S.A., Samosudova L.V., Pribylova N.N., Makhova O.Yu. Phenotypical heterogeneity of severe bronchial asthma and the analysis of its treatment in Kursk region. Kursk Scientific and Practical Bulletin "Man and His Health". 2016;(3):33-38. (In Russ.) https://doi.org/10.21626/vestnik/2016-3/06
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