Experimental score assessment of the clinical course of infected cornal burn in treatment by various methods

According to WHO data, nowadays at least 2.2 billion people worldwide currently have visual impairment or blindness, of which more than 11.9 million people worldwide have moderate to severe irreversible visual impairment that could be prevented.

Objective: to assess the clinical course of a standard infected corneal burn during treatment using combined ophthalmic medicinal films levofloxacin + dexpanthenol and dexamethasone + dexpanthenol from a comparative perspective.

Materials and methods. The article investigates the pharmacological activity of five different drug regimens for the treatment of an infected corneal burn in rabbits. Treatment of the first wave began 1 hour after the formation of a standard infected corneal burn. Treatment of the second wave began after the absence of signs of an inflammatory reaction was detected. The clinical course of the standard infected corneal burn was assessed immediately after the formation of the burn and the infection, 1 hour, 2, 3, 5 and 14 days after the experiment started.

Results. Clinical recovery began on the 3rd day in experimental group 2 treated with combined ophthalmic medicinal films of levofloxacin 1.5 mg + dexpanthenol 1 p/day. On the 5th day of the experiment, recovery was recorded in the experimental group 1 treated with 1.5 mg levofloxacin-based eye films once a day, as well as in comparison group 2 treated with 0.5% levofloxacin 4 times a day and 5% dexpanthenol 6 times a day. On the 7th day after the formation of a standard infected corneal burn, clinical recovery was recorded in comparison group 1 treated with instillations of levofloxacin 0.5% 4 times a day. In the control group with placebo treatment no conjunctiva inflammatory reaction was recorded on the 14th day of the experiment, however, there was persistent corneal opacity in the form of a spot at the burn site.

Conclusions. While treating a standard infected corneal burn, the use of combined ophthalmic medicinal films can shorten the clinical recovery period to 3 days, in comparison with treatment with instillations, where recovery occurred on the 5th day of the experiment.

1. Аветисов С.Э., Егоров Е.А., Мошетова Л.К., Нероев В.В., Тахчиди Х.П. Офтальмология: национальное руководство. 2-е изд., перераб. и доп. Москва: ГЭОТАР-Медиа, 2018. 904 с.

2. Азнабаев М.Т., Азаматова Г.А. Метод профилактики внутриглазных инфекций после факоэмульсификации катаракты с помощью глазной лекарственной пленки с левофлоксацином. Вестник Оренбургского государственного университета. 2010;12(118):8-10

3. Ивкина А.С., Ивкин Д.Ю., Семивеличенко Е.Д., Плиско Г.А., Буренков П.В. Моделирование травматических повреждений роговицы глаза. Лабораторные животные для научных исследований. 2018;2:30-37. DOI: 10.29296/2618723X-2018-02-04

4. Общероссийская общественная организация «Ассоциация врачей-офтальмологов». Клинические рекомендации: ожоги глаз. URL: http://avo-portal.ru/doc/fkr/approved/item/254-ozhogi-glaz

5. Общество офтальмологов России. Стандарт специализированной медицинской помощи при термических и химических ожогах, ограниченными областью глаза и его придаточного аппарата. URL: https://oor.ru/files/standarti/stand13.xlsx

6. American Academy of Ophthalmology. Chemical (Alkali and Acid) Injury of the Conjunctiva and Cornea URL: https://eyewiki.org/Chemical_(Alkali_and_Acid)_Injury_of_the_Conjunctiva_and_Cornea.

7. Deguchi H., Kitazawa K., Kayukawa K., Kondoh E., Fukumoto A., Yamasaki T., Kinoshita S., Sotozono C. The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study. PLoS ONE. 2018;13(9):e0203705. DOI: 10.1371/journal.pone.0203705

8. Flaxman S.R., Bourne R.R.A., Resnikoff S., Ackland P., Braithwaite T., Cicinelli M.V., Das A., Jonas J.B. et al. Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. Lancet Glob Health. 2017;5(12):e1221-e1234. DOI: 10.1016/S2214-109X(17)30393-5.

9. Jin H., Parker W.T., Law N.W., Clarke C.L., Gisseman G.D., Pflugfelder S.C., Wang L., Al Mohtaseb Z.N. Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital. British Journal of Ophthalmology. 2017;101(11):1483-1487. https://doi.org/10.1136/bjophthalmol-2016-310026

10. Kanski J., Bowling B. Kanski's Clinical Ophthalmology. 8 ed. Saunders Ltd, 2018. 928 p.

11. Medscape. Corneal Abrasion Treatment & Management. URL: https://emedicine.medscape.com/article/ 1195402-treatment

12. Porth J.M., Deiotte E., Dunn M., Bashshur R. A Review of the Literature on the Global Epidemiology of Corneal Blindness. Cornea. 2019;38(12):1602-1609. DOI: 10.1097/ICO.0000000000002122

13. Taylor H.R. Global blindness: the progress we are making and still need to make. Asia Pac J Ophthalmol (Phila). 2019;8(6):424-428. DOI: 10.1097/APO.0000000000000264

14. The Association for Research in Vision and Ophthalmology. Statement for the use of animals in ophthalmic and vision research. URL: www.arvo.org/About/policies/statement-for-the-use-of-animals-in-ophthalmic-and-vision-research.

15. Vos T., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulkader R.S., Abdulle A.M. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211-1259. DOI: 10.1016/S0140-6736(17)32154-2.

16. Willmann D., Moshirfar M., Melanson S.W. Corneal Injury. StatPearls. 2020. URL: https://www.ncbi.nlm. nih.gov/books/NBK459283.

17. World Health Organization. World report on vision. 2019. URL: https://www.who.int/publications/i/item/ world-report-on-vision.

18. Yarmamedov D., Lipatov V., Medvedeva M., Zaharova K. Study of the pharmacological impact of polymeric membranes with antibacterial effect in traumatic lesions of cornea. Research Results in Pharmacology. 2018;4(4):89-96. DOI: 10.3897/rrpharmacology.4.31006. URL: https://rrpharmacology.pensoft.net/article/31006/