Importance of using genetic markers in diagnostics and surgical treatment of patients with chronic arterial insufficiency

Sergey N. Zhabin; Svetlana S. Dudchenko; Alexandr K. Gavrikov; Darya I. Gavrikova; Tat’yana N. Legostayeva; Ilya S. Ivanov; Evgeny G. Ob’Edkov; Alexey V. Polonikov

doi:10.21626/vestnik/2019-4/05

Importance of using genetic markers in diagnostics and surgical treatment of patients with chronic arterial insufficiency

Sergey N. Zhabin, Svetlana S. Dudchenko, Alexandr K. Gavrikov, Darya I. Gavrikova, Tat’yana N. Legostayeva, Ilya S. Ivanov, Evgeny G. Ob’Edkov, Alexey V. Polonikov

https://doi.org/10.21626/vestnik/2019-4/05

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Abstract

For the timely diagnosis and prevention of peripheral arterial diseases (PAD) at the early stages, a further study of their pathogenesis is necessary. Today, foreign literature offers an in-depth study of this problem with the search for genetic biomarkers for early screening of patients suffering from asymptomatic forms of PAD, as well as those predisposed to this pathology. With the help of genetic determinants, it is possible to identify key mechanisms involved in the pathogenesis of PAD, thereby determining treatment tactics for more effective treatment. In this article, we have reviewed the progress made in studies related to the genetics of peripheral artery disease (PAD). We have discussed the considerable role of genetic factors, the interaction of genes and the environment in developing and / or progressing PAD; the potential role of biomarkers in identifying patients at risk for PAD and for stratification of this risk, new approaches for identifying reliable biomarkers for PAD. The efforts made nowadays in the areas of inheritance, linkage analysis and candidate gene research have been described in detail. We have reviewed the current research on the genome association (GWAS) and epigenetic studies, the current problems and future directions of advanced research in the field of genetics of PAD.