The relationship between polymorphism C667T of the MTHFR gene and ischemic heart disease risk in russian population of Central Russia
Abstract
It is well known that individuals with elevated levels of plasma homocysteine are high-risk group for ischemic heart disease (IHD). The methylenetetrahydrofolate reductase (MTHFR) enzyme is involved in folate metabolism and influences plasma homocysteine concentrations. The common variant C677T in MTHFR gene is associated with the decreased enzyme activity. The aim of this study was to investigate the association of polymorphisms C677T (rs1801133) of the MTHFR gene with the risk for IHD in population of Central Russia. We studied DNA samples obtained from 946 subjects, including 549 IHD patients and 397 sex- and age-matched healthy individuals. The polymorphisms were genotyped through a real-time PCR using TaqMan allele-discrimination assays. The comparative analysis showed no difference in allele and genotype frequencies of the MTHFR polymorphism between the cases and control groups. The analysis stratified by gender did not reveal the associations of the MTHFR gene C677T polymorphism with the IHD risk. The study showed that polymorphism C677T of the MTHFR gene is not a susceptibility gene for ischemic heart disease in Central Russia population.
About the Authors
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
E. M. Dolzhenkova
Kursk State Medical University
Russian Federation
Russian Federation
A. S. Baryshev
Kursk State Medical University
Russian Federation
Russian Federation
N. V. Ivanova
Kursk State Medical University
Russian Federation
Russian Federation
V. N. Ryzhaeva
Kursk State Medical University
Russian Federation
Russian Federation
N. S. Razinkova
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Bushueva O.Yu., Dolzhenkova E.M., Baryshev A.S., Ivanova N.V., Ryzhaeva V.N., Razinkova N.S., Polonikov A.V. The relationship between polymorphism C667T of the MTHFR gene and ischemic heart disease risk in russian population of Central Russia. Kursk Scientific and Practical Bulletin "Man and His Health". 2015;(4):76-80. (In Russ.)
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