Indicators of saliva secretory immunity in patients with various diseases of salivary glands
Abstract
The article touches upon the evaluation of the secretory immune indicators of saliva in 96 elderly people (aged from 61 to 74) with various diseases of salivary glands (sialadenitis, sialosis, benign tumors, and malignant tumors). The proprtion of immunoglobulins IgA, IgM, IgG, secretory IgA, as well as inflammatory (IL -1β, interleukin-6, interleukin-8, tumor necrosis factor-α) and anti-inflammatory (interleukin-1, interleukin-4, and interleukin -10 receptor antagonists) cytokines in saliva, and the defensin level were investigated with ELISA. The study found that all patients showed a significant decrease in the concentration of sIgA in saliva. The study of the cytokine proportion in saliva in patients with sialadenitis and sialosis revealed inflammatory cytokines (IL-6) being predominant over anti-inflammatory (IL-10), the opposite picture was found in patients with benign tumors of salivary glands. In patients with malignant tumors we observed a sharp increase in both inflammatory and anti-inflammatory cytokines in saliva. These changes may cause an imbalance in the local mucosal immune response and the development of both autoimmune and inflammatory diseases of the oral cavity.
About the Authors
M. E. Malyshev
Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine, St. Petersburg
Russian Federation
Russian Federation
V. V. Lobeyko
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
Russian Federation
Russian Federation
A. K. Iordanishvili
S.M. Kirov Military Medical Academy, St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Malyshev M.E., Lobeyko V.V., Iordanishvili A.K. Indicators of saliva secretory immunity in patients with various diseases of salivary glands. Kursk Scientific and Practical Bulletin "Man and His Health". 2015;(1):40-47. (In Russ.)
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