Clinical and immunological efficiency of polymuramil in complex treatment of patients with perianal fistulas
https://doi.org/10.21626/vestnik/2018-4/09
Abstract
The influence of traditional therapy supplemented with polymuramil on the cellular immunity of patients with perianal fistulas was investigated. It was found that the development of pararectal fistulas is accompanied by forming a pronounced imbalance in lymphocyte subpopulations. Summarizing the effectiveness of treatment options in patients with chronic paraproctitis according to the indicators different from the normal level revealed that the additional appointment of polymuramil to the standard treatment plan allowed normalizing 70.0% and correcting 10.0% of the indicators changed. Thus, the additional appointment of polymuramil to the standard therapeutic plan leads to a pronounced correction of impaired immunological parameters, which affects the clinical effectiveness of the treatment in this category of patients.
About the Authors
E. Yu. Zaikin
St. Joasaph Belgorod Regional Clinical Hospital
Russian Federation
Russian Federation
V. A. Lazarenko
Kursk State Medical University
Russian Federation
Russian Federation
P. V. Kalutsky
Kursk State Medical University
Russian Federation
Russian Federation
O. V. Kalyuzhin
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
N. G. Bakhtina
LLC “Maxbelmed”
Russian Federation
Russian Federation
E. I. Mukhanova
St. Joasaph Belgorod Regional Clinical Hospital
Russian Federation
Russian Federation
References
1. Гланц С. Медико-биологическая статистика. Пер. с англ. - М. : Практика, 1998. - 459 с. [Glants S. Biomedical statistics. Transl. from Eng. - Moscow : Praktika; 1998: 459 (in Russ.)].
2. Гублер Е.В., Генкин А.А. Применение непараметрических критериев статистики в медико-биологических исследованиях. Издание 2-е. - Л. : Медицина, 1973. - 141 с. [Gubler E.V., Genkin A.A. Application of non-parametric criteria of statistics in biomedical research. 2nd Edition. - Leningrad : Meditsina; 1973: 141 (in Russ.)].
3. Земсков А.М., Земсков В.М. Дополнительные аспекты оценки иммунного статуса // Клиническая лабораторная диагностика. - 1994. - № 5. - С. 91-98. [Zemskov A.M., Zemskov V.M. Additional aspects of the assessment of the immune status. Klinicheskaya laboratornaya diagnostika. 1994; (5): 91-98. (in Russ.)].
4. Клиническая иммунология и аллергология (2-е изд.) // Под ред. A.B. Караулова. - М. : МИА, 2002. - 651 с. [Clinical Immunology and Allergology. 2nd ed. A.V. Karaulov, editor. Moscow : MIA; 2002: 651 (in Russ.)].
5. Кошелев П.И., Резников К.М., Гридин А.А. Лечение гнойных ран с применением анолита и католита // Системный анализ и управление в биомедицинских системах. - 2005. - Т. 4, № 1. - С. 54-56. [Koshelev P.I., Reznikov K.M., Gridin A.A. Treatment of purulent wounds with application anolyte and katholyte. Sistemnyy analiz i upravleniye v biomeditsinskikh sistemakh. 2005; 4(1): 54-56 (in Russ.)].
6. Пащенков М.В., Будихина А.С., Голубева Н.М., Алхазова Б.И., Львов В.Л., Ступин В.А., Привиденцев А.И., Трушин С.Н., Селиверстов Д.В., Огорельцев А.Ю., Пинегин Б.В., Хаитов Р.М. Результаты II/III фазы клинических испытаний иммуномодулятора «Полимурамил» при гнойной хирургической инфекции // Иммунология. - 2012. - Т. 33, № 4. - С. 199-203. [Pashenkov M.V., Budikhina A.S., Golubeva N.M., Alkhazova B.I., L’vov V.L., Stupin V.A., Prividentsev A.I., Trushin S.N., Seliverstov D.V., Ogorel'tsev A.Yu., Pinegin B.V., Khaitov R.M. Results of a phase ii/iii clinical trial of an immunomodulator polymuramyl in patients with purulent surgical infections. Immunologiya. 2012; 33(4): 199-203 (in Russ.)].
7. Федоров В.Д., Воробьев Г.И., Ривкин B.Л. Клиническая оперативная колопроктология: Рук. для врачей. - М., 1994. - 450 с. [Fedorov V.D., Vorob’yev G.I., Rivkin B.L. Clinical operative coloproctology: A guide for physicians. Moscow; 1994: 450 (in Russ.)].
8. Vasilevsky C.A., Gordon P.H. The incidence of recurrent abscess or fistula-in-ano following anorectal suppuration // Dis. Colon. Rectum. - 1984. - Vol. 27. - P. 126-130. - doi:10.1007/BF02553995
9. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects // JAMA. - 2013. - Vol. 310, N 20. - P. 2191-2194. - DOI: 10.1001/jama.2013.281053.
Review
For citations:
Zaikin E.Yu., Lazarenko V.A., Kalutsky P.V., Kalyuzhin O.V., Bakhtina N.G., Mukhanova E.I. Clinical and immunological efficiency of polymuramil in complex treatment of patients with perianal fistulas. Kursk Scientific and Practical Bulletin "Man and His Health". 2018;(4):56-60. (In Russ.) https://doi.org/10.21626/vestnik/2018-4/09
Views:
558
Email this article 