Selank influence on morphological state of rat hepatocytes under acute restraint stress
https://doi.org/10.21626/vestnik/2017-4/19
Abstract
We studied effects of Selank on morphological state of liver tissue in Wistar male rats exposed to acute restraint stress. Selank was administrated by intraperitoneal injections of 100, 300 and 1,000 µg/kg 15 min before stress onset. We discovered that acute restraint stress led to the development of hydropic degenetation of hepatocytes, growing percentage of hepatocytes with one nucleolus, reduction in hepatocyte area due to reducing cytoplasm. The changes above-mentioned were more prominent in peripheral zone of liver lobule. Selank showed ameliorative effect on hydropic degeneration in a dose-dependent manner. The administration of 100 and 1,000 µg/kg Selank increased the percentage of hepatocytes with one nucleolus in peripheral and central zones of liver lobule. Peptide application in a dose of 300 µg/kg resulted in the growth of hepatocyte area due to increasing cytoplasm in peripheral and central zones of liver lobule.
About the Authors
E. V. Fomenko
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Ivanov
Kursk State Medical University
Russian Federation
Russian Federation
I. I. Bobyntsev
Kursk State Medical University
Russian Federation
Russian Federation
A. E. Belykh
Kursk State Medical University
Russian Federation
Russian Federation
N. K. Garbelotto
Kursk State Medical University
Russian Federation
Russian Federation
L. A. Andreeva
Institute of Molecular Genetics of Russian Academy of Science
Russian Federation
Russian Federation
N. F. Myasoedov
Institute of Molecular Genetics of Russian Academy of Science
Russian Federation
Russian Federation
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Review
For citations:
Fomenko E.V., Ivanov A.V., Bobyntsev I.I., Belykh A.E., Garbelotto N.K., Andreeva L.A., Myasoedov N.F. Selank influence on morphological state of rat hepatocytes under acute restraint stress. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(4):108-114. (In Russ.) https://doi.org/10.21626/vestnik/2017-4/19
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