Evaluation of the functional instability degree in exacerbation of CHD

Abstract

The article presents data on the possibility of diagnosing the depth of functional disorders revealed in 60 patients with coronary artery disease against the background of developing acute coronary syndrome. It is shown that the analysis of the nonlinear dynamics of the information indicator of cardiorhythm - entropy serves as a basis for the presentation of systemic homeokinesis in the form of its attractor model with measurable topological features. It was established that the development of non-Q myocardial infarction as an outcome of acute coronary syndrome without ST segment elevation by the end of the second day is accompanied by significantly greater functional instability in comparison with that in persons without irreversible myocardial lesions, which corresponds to statistically significant changes in the topology of the attractor of entropy dynamics of cardiorhythm. The proposed quantitative indicators reflecting this phenomenon can be considered as additional alternative informative markers as the very effect of instability of the organization of systemic homeostatic regulation against the background of acute somatic pathology, and can serve as its quantitative measure.