Influence of anti-B-cell therapy on the pro-inflammatory cytokinemia and structural-functional parameters of the vascular wall in patients with rheumatoid arthritis

N. S. Meshcherina

Influence of anti-B-cell therapy on the pro-inflammatory cytokinemia and structural-functional parameters of the vascular wall in patients with rheumatoid arthritis

N. S. Meshcherina

Abstract

The article presents the results of the research of Rituximab (monoclonal antibodies to superficial receptors of CD20-lymphocytes) impact on the proinflammatory cytokine level and structural-functional properties of the common carotid artery (CCA) in 48 patients with the varying duration of Jg M-RF-seropositive rheumatoid arthritis (RA). It was determined that patients with the developed RA had significantly higher levels of TNF-α, sTNF-α-r1, IL-1β and IL-17, while the concentration of IL-6 and sIL-6 was significantly increased in the late stage disease. The following signs of pathological CCA remodeling were determined: the increase in intimae-media complex (IMC) thickness, the increase in CCA diameter and rigidity index; these changes were progressing during the course of the disease. The correlational analysis revealed the significant direct correlational relationship between DAS28 index, the proinflammatory cytokine level, IMC thickness and CCA diameter in patients with RA. Apart from the anti-inflammatory activity, the treatment of patients with RA with Rituximab also had a vasoprotective action, which was more efficient if the disease duration did not exceed 2 years.

Keywords

провоспалительные цитокины, ревматоидный артрит, ремоделирование сосудистого русла, ритуксимаб, proinflammatory cytokines, rheumatoid arthritis, vasculature remodeling, Rituximab

About the Author

N. S. Meshcherina

Kursk State Medical University
Russian Federation

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Review

For citations:

Meshcherina N.S. Influence of anti-B-cell therapy on the pro-inflammatory cytokinemia and structural-functional parameters of the vascular wall in patients with rheumatoid arthritis. Kursk Scientific and Practical Bulletin "Man and His Health". 2013;(4):96-102.

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1998-5746 (Print)
ISSN 1998-5754 (Online)

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Humans and their health

Influence of anti-B-cell therapy on the pro-inflammatory cytokinemia and structural-functional parameters of the vascular wall in patients with rheumatoid arthritis

Abstract

Keywords

About the Author

References

Review

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