Comparative characteristic of the influence of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio) acetate and bemityl on the physical endurance of rats under long hypokinesia

Abstract

The experiments on rats revealed a decrease in physical endurance of animals resulted from long-term hypokinesia (18 days) proved by the statistically significant reduction in the duration of the swimming test and in time of animals’ hold on the rotating bar. The course introduction of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio) acetate (1.7 mg/kg intraperitoneally) equally to Bemityl (32 mg/kg intraperitoneally) to rats in the experimental conditions contributed to the increase both in dynamic and static endurance of animals. It proved the presence of actoprotective activity in КВ-28 like in the reference drug. The ability of КВ-28 to increase physical endurance was increasingly expressed in the phase of anxiety and resistance (3^d and 13^th days) of general adaptation syndrome and as for Bemityl - into the phase of anxiety.