Influence of infusion solutions on dynamics of neuron specific enolase and S 100 protein activities in rats in conditions of acute cerebral circulation disorder

Abstract

On the model of an experimental ischemic postperfusion brain damage the characteristic of the influence of solutions HAES-LX-5%, Voluven and 0.9% NaCl on the activity of NSE and the level S 100 protein was given. Pharmacotherapy of modeling postperfusion syndrome by the infusion solutions of Voluven and HAES-LX-5% inhibited the development of neuronal necrosis that manifested itself by the reliably lower levels of NSE activity both on the 4^th and on the 7^th day of the experiment comparing with 0.9% NaCl solution. The infusion therapy with 0.9% NaCl, Voluven and mostly HAES-LX-5% solutions of the acute cerebral circulation disorder that occurred against the background of the infarct depended vessels reocclusion contributed to decreasing in neuroglia formation and development of inflammatory reactions in it proved by the reliable decreasing in S 100 protein titers in respect to the control pathology group. The influence of Voluven and HAES-LX-5% solutions on the activity and level of neuromarkers of NSE and S 100 protein in the blood serum of rats in the postperfusion period of the modeling stroke, indicate that cerebroprotective effect of Voluven and HAES-LX-5% is connected with the inhibition of neuronal necrosis.