Giant foreign body cells and tissue reactions on the surface of implants
https://doi.org/10.21626/vestnik/2017-3/15
Abstract
The rewiev presents analysis of the literature data concerning the problem of tissue reactions on implantats with different properties. The main part contains the data about morphological and functional characteristics of foreign body giant cells (FBGC), mechanisms and regulatory factors of their formation. The published data show that on the border tissues - surface of implantats the unique medium is formed with participation and interactions of plasma and tissue proteins. The survival of cells on the surface of biomaterials depends on adhesive features of implanted material and absorbed proteins. The fusion of macrophages with the formation of GFBC occurs due to mоlecules of integrins family, and is followed by cytoskeleton modifications with the formation of specialized organelles - podosomes, is regulated by wide spectrum of cytokins (ILs, TNF and other) of lymphocytic and autologous origin. Lightmicroscopic criteria of GFBC evaluation are following: the number of cells, their size, shape, the number and location of nuclei, fuso-amitotic index(a ratio between the number of cells with signs of fusion and cells with amitotic morphology).
About the Authors
A. A. Dolzhikov
Belgorod State National Research University
Russian Federation
Russian Federation
A. Ya. Kolpakov
Belgorod State National Research University
Russian Federation
Russian Federation
A. L. Yarosh
Belgorod State National Research University
Russian Federation
Russian Federation
A. S. Molchanova
Belgorod State National Research University
Russian Federation
Russian Federation
I. N. Dolzhikova
Belgorod State National Research University
Russian Federation
Russian Federation
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Review
For citations:
Dolzhikov A.A., Kolpakov A.Ya., Yarosh A.L., Molchanova A.S., Dolzhikova I.N. Giant foreign body cells and tissue reactions on the surface of implants. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(3):86-94. (In Russ.) https://doi.org/10.21626/vestnik/2017-3/15
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