Pharmacological treatment of experimental critical limb ischemia

Abstract

The effectiveness of Myelopid, Actovegin and Solcoseryl in the treatment of critical limb ischemia was experimentally studied on 130 white male rats Wistar. Experimental animals were divided into 5 groups: intact, control, and three experimental ones. The intact group consisted of 10 rats with the normal level of microcirculation. Other groups included 30 animals to be modeled the critical ischemia of a right hind limb. The control group had no treatment. The first group of experimental animals received Myelopid, the second one - Actovegin, and the third one - Solcoseryl. It was established that Myelopid significantly better activated the processes of microcirculation in the ischemic limb as compared to antihypoxants. The improvement of microcirculation increased the density of capillary network and reduced the specific area of necrotic muscle tissue. In the later stages of the experiment Actovegin surpassed Solcoseryl in the positive effect on the regenerative process in the ischemic tissue.