Высокодозная иммуносупрессивная терапия с аутологичной трансплантацией гемопоэтических стволовых клеток как эффективный метод лечения аутоиммунных заболеваний

К настоящему времени накоплены данные, указывающие на высокую эффективность метода высокодозной иммуносупрессивной терапии с аутологичной трансплантацией гемопоэтических стволовых клеток (ВИСТ-АТГСК) и возможность сохранения и улучшения качества жизни пациентов с аутоиммунными заболеваниями (АИЗ) после него. Опыт применения ВИСТ-АТГСК в мире к 2025 году составляет 30 лет, в нашей стране - 27 лет. Однако, несмотря на это, метод до сих пор считается экспериментальным и не входит в Клинические рекомендации соответствующих нозологий.

Цель - представить эффективный, потенциально однократно применяемый метод лечения АИЗ; описать мировой опыт применения ВИСТ-АТГСК при лечении некоторых АИЗ.

В статье описаны точки приложения и возможности метода иммунной реконституции для стабилизации и лечения тяжелых аутоиммунных заболеваний, таких как системная склеродермия, системная красная волчанка, ревматоидный артрит, болезнь Крона, сахарный диабет 1 типа, рассеянный склероз. ВИСТ-АТГСК является высокоэффективным методом лечения агрессивных и рефрактерных форм АИЗ при условии своевременного его применения на этапе преобладания активного аутоиммунного воспаления над процессами поражения органов и систем-мишеней.

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