Immunomodulatory effect of Thymogen analogues in toxic liver injury

Objective - to study the effects of thymogen and its structural analogs on the functional activity of blood neutrophils in toxic liver damage with tetrachloromethane and hydrazine hydrochloride. Materials and methods. Carbon tetrachloride hepatopathy accompanied by an increase in immune reactivity was modeled by a 5-fold intragastric administration of carbon tetrachloride. Liver damage with hydrazine associated with immunosuppression was induced by a single intraperitoneal administration of a hepatotropic poison. Rats were administered thymogen (1 μg/kg) and its structural analogues (1.2 μg/kg) intraperitoneally for 5 days. In carbon tetrachloride hepatopathy, peptides were administered simultaneously with the hepatotropic poison, in hydrazine - 24 hours after intoxication. Phagocytic and oxygen-dependent activities of neutrophils were assessed. Results. It was found that in liver damage by carbon tetrachloride, thymogen does not exert a corrective effect on the functional activity of neutrophils. Structural analogues reduced the activity of neutrophils under conditions of hyperactivation of the immune system. In hydrazine hepatopathy, all peptides exhibited immunostimulating activity, with its greater expression in structural analogs of thymogen. Conclusion. Thymogen analogues modified with D-alanine exert an immunomodulatory effect in toxic hepatopathies with different levels of immune reactivity.

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