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Immunological factors as predictors of chronic acute urticaria

https://doi.org/10.21626/vestnik/2023-1/04

EDN: QNPWSD

Abstract

Objective: to conduct a comparative analysis of the level of α-defensins (HNP1-3) and cytokines (IL-8, IL-4, IL-17, TNFα) to identify predictors of chronic acute urticaria. Materials and methods. There were 57 patients under observation with acute recurrent urticaria, divided by the level of serum IgE into 3 groups: group 1 - patients with IgE levels up to 100 IU / ml, group 2 - with IgE from 100 to 500 IU / ml, group 3- with IgE over 500 IU / ml. The quantitative content of α-defensins (HNP 1-3) in blood plasma and cytokines (IL-8, IL-4, IL-17A, TNF-α), IgE in blood serum was determined by solid-phase ELISA. Rusults. The study showed that in all patients with acute urticaria there was an increase in the level of serum cytokines (IL-8, IL-17A, TNF-α) and α-defensins HNP 1-3, the most pronounced in patients of group 3 with an IgE level of more than 500 IU/ml According to the results of correlation analysis, the strongest direct correlation was found between the level of α-defensins HNP 1-3 and IL-17A. In patients of groups 2 and 3, a strong direct correlation was also found between the level of HNP 1-3 and TNFα. Conclusion. The results of the study showed that a significant increase in the level of cytokines IL-4, IL-8, IL-17A, TNF-α and α-defensins (HNP1-3) in patients with acute recurrent urticaria indicates their key role in the pathogenesis of the disease. The revealed direct correlation between the levels of α-defensins, IL-17A and TNF-α reflects the dynamics of the course of immunoinflammatory process and can be regarded as predictors of chronic acute urticaria.

About the Authors

Svetlana M. Yudina
Kursk State Medical University (KSMU)
Russian Federation

Dr. Sci. (Med.), Professor, Head of the Department of Clinical Immunology, Allergology and Phthisiopulmonology, KSMU, Kursk, Russian Federation


Tatyana S. Rusanova
Kursk State Medical University (KSMU)
Russian Federation

Cand. Sci. (Med.), Associate Professor at the Department of Clinical Immunology, Allergology and Phthisiopulmonology, KSMU, Kursk, Russian Federation


Inna A. Ivanova
Kursk State Medical University (KSMU)
Russian Federation

Cand. Sci. (Med.), Associate Professor, Associate Professor at the Department of Clinical Immunology, Allergology and Phthisiopulmonology, KSMU, Kursk, Russian Federation


Evgenia A. Krivonkina
Emergency Hospital
Russian Federation

allergist-immunologist, Emergency Hospital, Petrozavodsk, Russian Federation


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Review

For citations:

Yudina S.M., Rusanova T.S., Ivanova I.A., Krivonkina E.A. Immunological factors as predictors of chronic acute urticaria. Humans and their health. 2023;26(1):27-32. (In Russ.) https://doi.org/10.21626/vestnik/2023-1/04. EDN: QNPWSD

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ISSN 1998-5746 (Print)
ISSN 1998-5754 (Online)

Humans and their health
Kursk State Medical University
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