Assessment of hemostasis in newborns with necrotizing enterocolitis

During the newborn period, the hemostatic system undergoes a number of changes that cause it to be less stable under any adverse effects. This is especially evident in premature and low-weight children by the time of gestation. One of the damaging factors that affects the hemostatic system is the infectious-inflammatory process. Modern integral methods of hemostasis assessment, such as thromboelastography and thrombodynamics, most fully reflect the state of the coagulation system. 

The purpose of this study was to study the features of hemostasis in non-surgical stages of necrotizing enterocolitis (NEC) in premature newborns. 

Materials and methods. A total of 86 children were examined in the neonatal period. The main group included 62 children with NEC, the control group included 24 newborns with perinatal CNS lesions. Children of both groups were comparable in gestational age and mass-growth indicators. In addition to the generally accepted methods of the hemostasis research, integral methods were used - thrombodynamics and thromboelastography. 

Results. Global methods for assessing hemostasis in newborns with NEC have revealed hypercoagulation and a tendency to thrombosis in more than 70% of children in the main group and only 10% of children in the control group. When analyzing only the indicators of the standard coagulogram, there were no significant differences in terms of hemostasis disorders in the compared groups.