Association study of genetic polymorphisms of inherited thrombophilia genes with clinical and laboratory parameters in patients after reconsntructive surgery for obliterating diseases of abdominal aorta and lower limb arteries

Abstract

We investigated the association of genetic polymorphisms of hereditary thrombophilia 1691G / A FV, 20210G / A FII, 677 C / T MTHFR, 455 G / A FGB with clinical and laboratory parameters of lipid metabolism and hemostasis factors in 119 patients (men) who had undergone reconstructive surgery on abdominal aorta and arteries of lower extremities, divided into three groups. The first group included patients with thrombosis of the reconstruction zone within the first 6 months after surgery (n = 44), the second group included patients without thrombosis of the reconstruction zone (n = 40), the third group consisted of men without symptoms of obliterating diseases of aorta and lower limb arteries (n = 35). The comparative analysis revealed the reliable relations of genetic variants 20210 GA FII with elevated levels of homocysteine and D-dimer test, genetic variants of 455 GA FGB and 455 AA FGB with elevated levels of D-dimer test. Genetic variants of CT 677 and CT 677 MTHFR are associated with the increased levels of triglycerides in blood and shortening of thrombin time, and the TT genotype of MTHFR 677 is associated with the reduced level of high density lipoproteins in blood.