Kinetics of blood oxygen consumption in patients with atherosclerosis

Abstract

Objective. The purpose of the study was to evaluate the kinetics of blood oxygen consumption in patients with atherosclerosis of various vascular pools. Materials and methods. We examined 47 patients with atherosclerosis including 25 patients with primary damage of brachiocephalic arteries and 22 patients with obliterating atherosclerosis of arteries of lower extremities. The diagnosis of atherosclerosis was established on the basis of ultrasonic duplex scanning and was confirmed by the data of angiography. The kinetics of the induced oxygen consumption in blood plasma was studied using the biological oxygen monitor. To generate free radicals formation we used 2,2’-Azobis(2-amidinopropane) dihydrochloride (AAPH). Results. We found the increased blood oxidation rate and the increase in parameters of oxygen consumption per 1 minute, oxygen consumption rate at the 30th and 40th minutes and also the decrease in oxygen semi-consumption period in patients with atherosclerosis with primary damage of brachiocephalic and peripheral arteries versus the controls. The increase in blood oxygen consumption in patients with atherosclerosis which was revealed at the 30th minute proved a higher initial level of peroxide oxidation of lipids, the increase in concentration of peroxidation products and fast exhaustion of antioxidant system as compared to the controls, with some decrease in oxygen consumption by the 40th minute that corresponded to kinetics of free radicals recession. Conclusion. Due to the systemic character of atherosclerotic process, the increase in oxygen consumption parameters which might reflect a high reactogenicity of oxidation substrate or an antioxidant defense system failure is observed in patients with atherosclerosis regardless of the primary localization of atherosclerotic damage.