Studying the role of 279 G/A cholesteryl ester transfer protein gene polymorphism in the development of acute pancreatitis

Abstract

The aim of the study was to investigate the association of 279 G/A polymorphism of CETP gene with the risk for acute pancreatitis in Russian population. Whole blood samples were collected from 281 patients with acute pancreatitis and 200 healthy people. Polymorphism Genotyping 279 G/A CETP gene was accomplished by using PCR with allele discrimination with TaqMan-probes. There is no association of polymorphisms of 279 G/A CETP gene with the development of acute nonbiliary pancreatitis. We conducted a stratified analysis by sex, among smokers - no differences were found in the groups of patients and healthy individuals. Since alcohol abuse takes a particular place among the risk factors for acute pancreatitis, we studied the effect of the drink volume (up to 199g and 200g and> pure ethanol per week), the frequency of its consumption (2 or less times a month and more than once a week), and duration (up to 10 years and more than 10 years). It was found that the volume and frequency of taking alcoholic beverages did not change the general picture of the association of genotypes with the risk for developing acute pancreatitis.