Efficiency of combined application of histochrome and Poludanum in complex therapy of patients with keratoconjunctivitis exposed to anomalous geomagnetic field

Abstract

The immuno-metabolic and clinical efficacy of combined application of histochrome and Poludanum was studied in the complex therapy of patients with bacterial keratoconjunctivitis residing in the area of Kursk magnetic anomaly with a high level of natural geomagnetic field. According to the indicators of aggregate impact on immuno-metabolic status and clinical manifestations of the disease the combination of standard therapy with intramuscular introduction of histochrome and instillation of Poludanum was considered more effective. The use of the complex therapy with histochrome and Poludanum caused 33.3% of the investigated immuno-metabolic blood parameters, 29.6% of mixed saliva indicators and 29.4% of lacrimal fluid indicators with no significant differences from the healthy values in the region (during the standard therapy, the percentage of normalized indicators in blood, saliva and lacrimal fluid made up 22.2%, 29.6% and 29.6%, respectively). After applying the complex therapy the expressed reduction in the level of discomfort made 5.5 points, in itching 2.55 points, in discharge- 3.9 points, in conjunctiva oedema - 3.55 points (after the standard treatment those indicators made up 4.3, 2.2, 2.95 and 2.85 GPA, respectively).