Influence of Omacor on arrhythmic activity indicators and heart rate variability in patients with acute myocardial infarction
https://doi.org/10.21626/vestnik/2017-1/07
Abstract
We conducted the open-label randomized trial (n=60) to estimate antiarrhythmic effect of Omacor and its influence on the parameters of heart rate variability. The patients were divided into two groups, the basic group patients (n=30) were added Omacor in a dose of 1 g/day to the complex therapy, the control group patients were given the standard drug therapy. In the basic group a decrease in the total number of supraventricular extra systoles was noted as compared to the control one, as well as an increase in the level of parasympathetic and neurohumoral regulation of the heart activity that might have a beneficial effect on the subsequent treatment.
About the Authors
V. P. Mikhin
Kursk State Medical University
Russian Federation
Russian Federation
A. I. Shveynov
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Kharchenko
Kursk State Medical University
Russian Federation
Russian Federation
D. A. Vasilyeva
Kursk State Medical University
Russian Federation
Russian Federation
V. V. Savelyeva
Kursk State Medical University
Russian Federation
Russian Federation
E. V. Antopolskaya
Kursk State Medical University
Russian Federation
Russian Federation
G. V. Panchenko
Kursk City Clinical Emergency Hospital
Russian Federation
Russian Federation
References
1. Арутюнов Г.П. Терапевтические аспекты диагностики и лечения заболеваний сердца и сосудов / под ред. Г.П. Арутюнова - М. : ГЭОТАР-Медиа, 2015. - 608 с.
2. Михин В.П., Мальцева Л.С. Влияние омакора на вариабельность сердечного ритма и ишемические изменения в миокарде у больных хронической ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа // Архив внутренней медицины. - 2013. - № 1 (9). - С. 25-32.
3. Михин В.П., Мальцева Л.С., Громнацкий Н.И. Изменение аритмической активности у больных ИБС с нарушением ритма в сочетании с сахарным диабетом на фоне комплексной терапии Омакором // Курский научно-практический вестник «Человек и его здоровье». - 2012. - № 1. - С. 108-112.
4. Моисеев С.В. n-3 Полиненасыщенные жирные кислоты: о чем свидетельствуют результаты последних мета-анализов? // Клиническая фармакология и терапия. - 2013. - № 22(1) - С. 23-28.
5. Amiano P., Machón M., Dorronsoro M., Chirlaque M.D., Barricarte A., Sánchez M.J., Navarro C., Huerta J.M., Molina-Montes E., Sánchez-Cantalejo E., Urtizberea M., Arriola L., Larrañaga N., Ardanaz E., Quirós J.R., Moreno-Iribas C., González C.A. Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study // Nutrition, metabolism & Cardiovascular Diseases. - 2014. - Vol. 24, N 3. - P. 321-327. - doi: 10.1016/j.numecd.2013.08.011.
6. Din J.N., Archer R.M., Harding S.A., Sarma J., Lyall K., Flapan A.D., Newby D.E. Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in male cigarette smokers // Heart. - 2013. - Vol. 99, N 3. - P. 168-174. - doi: 10.1136/heartjnl-2012-302924.
7. GISSI-Prevenzione investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial // Lancet. - 1999. - Vol. 354, N 9177. - P. 447-455.
8. Haberka M., Mizia-Stec K., Mizia M., Gieszczyk K., Chmiel A., Sitnik-Warchulska K., Gąsior Z. Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction // Pharmacological reports. - 2013. - Vol. 65, N 1. - P. 59-68.
9. Khoueiry G., Abi Rafeh N., Sullivan E., Saiful F., Jaffery Z., Kenigsberg D.N., Krishnan S.C., Khanal S., Bekheit S., Kowalski M. Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. // Heart & Lung. - 2013. - Vol. 42, N 4. - P. 251-256. - doi: 10.1016/j.hrtlng.2013.03.006.
10. Lown B., Wolf M. Approaches to sudden death from coronary heart disease. Circulation. - 1971. -Vol. 44, N 1. - P. 130-142.
11. Tavazzi L., Maggioni A.P., Marchioli R., Barlera S., Franzosi M.G., Latini R., Lucci D., Nicolosi G.L., Porcu M., Tognoni G.; Gissi-HF Investigators. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized double-blind, placebo-controlled trial // Lancet. - 2008. - Vol. 372, N 9645. - P. 1223-1230. - doi: 10.1016/S0140-6736(08)61239-8.
12. Wen Y.T., Dai J.H., Gao Q. Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: A meta-analysis of randomized controlled trials // Nutrition, metabolism & Cardiovascular Diseases. - 2014. - Vol. 24, N 5. - P. 470-475. - doi: 10.1016/j.numecd.2013.12.004.
Review
For citations:
Mikhin V.P., Shveynov A.I., Kharchenko A.V., Vasilyeva D.A., Savelyeva V.V., Antopolskaya E.V., Panchenko G.V. Influence of Omacor on arrhythmic activity indicators and heart rate variability in patients with acute myocardial infarction. Kursk Scientific and Practical Bulletin "Man and His Health". 2017;(1):40-45. (In Russ.) https://doi.org/10.21626/vestnik/2017-1/07
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