Evidence of poisoning with cyclopentolate introduced into the stomach of warm-blooded animals on the basis of detecting initial poisoning agents and products of its transformation in the organisms
https://doi.org/10.21626/vestnik/2016-4/17
Abstract
The evidence of poisoning with cyclopentolate after its introduction into the stomach of warm-blooded animals on the basis of detecting the initial toxic substance and its structurely related compounds (transformation products) in poisoned organisms was considered. After the intragastric administration of 1.5 LD50 of cyclopentolate into the body of warm-blooded animals (rats), the initial toxic agent and possible products of its transformation in the organs and blood of poisoned organisms were searched for in a series of predetermined time intervals.The presence of cyclopentolate in all the investigated organs and blood of poisoned animals was established. The substance structurely similar to cyclopentolate -2-(dimethylamino)aethyl-(1.2-dehydrocyclo-pentyl)(phenyl)acetate - was observed and identified in the liver, kidneys, blood, spleen, heart, and muscles. The possibility to prove the poisoning with cyclopentolate on the base of detecting the initial poisoning agent and the possible product of its transformation- 2-(dimethylamino)aethyl-(1,2-dehydrocyclo-pentyl)(phenyl)acetate - in poisoned organisms was substantiated.
Keywords
циклопентолат,
2-(диметиламино)этил-(1,
2-дегидроцикло-пентил)(фенил)ацетат,
обнаружение в организме и идентификация,
доказательство отравлений,
cyclopentolate,
2-(dimethylamino)aethyl-(1,
2-dehydrocyclo-pentyl)(phenyl)acetate,
detection in the organism and identification,
the evidence of the poisoning
About the Authors
V. K. Shormanov
Kursk State Medical University
Russian Federation
Russian Federation
M. F. Pravdyuk
National Narcological Dispensary of Ministry of Health of Republic of North Ossetia-Alania
Russian Federation
Russian Federation
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Review
For citations:
Shormanov V.K., Pravdyuk M.F. Evidence of poisoning with cyclopentolate introduced into the stomach of warm-blooded animals on the basis of detecting initial poisoning agents and products of its transformation in the organisms. Kursk Scientific and Practical Bulletin "Man and His Health". 2016;(4):100-105. (In Russ.) https://doi.org/10.21626/vestnik/2016-4/17
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