Optimization of the deep necrosis treatment results supported by rational necrectomy in the experiment

Abstract

The problem of managing patients with deep necrosis of the skin and soft tissue remains relevant. Selecting necrectomy volume, timing of its implementation, the boundaries of performing surgical incisions are still not fully resolved. Necrosectomy against the background of the DSLET combination (10 mg / kg) and serotonin adipate (4.5 mg / kg) resulted in a decrease in the severity and prevalence of alternative changes in simulating deep necrosis of the skin and soft tissues. On the 3d day the granulation tissue was formed in wound edges. By the end of the experiment the whole damage area was formed by connective tissue with the newly produced dense collagen fibers indicating the maturation of connective tissue in the generating scar. The suggested method results in a maximum decrease in mortality to 16.6% and also reduces the lethality of animals by 10.9% as compared to the experimental group without necrectomy.