Association of vitamin D receptor rs1544410 gene polymorphism with autoimmune thyroiditis in women of reproductive age

Ivan A. Plakhotnikov; Yanina S. Valigun; Eduard A. Maylyan; Ksenia E. Tkachenko

doi:10.21626/vestnik/2024-2/05

Association of vitamin D receptor rs1544410 gene polymorphism with autoimmune thyroiditis in women of reproductive age

Ivan A. Plakhotnikov, Yanina S. Valigun, Eduard A. Maylyan, Ksenia E. Tkachenko

https://doi.org/10.21626/vestnik/2024-2/05

EDN: NPTLZR

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Abstract

Objective - to study the associations of vitamin D receptor (VDR) rs1544410 gene polymorphism with autoimmune thyroiditis in women. Materials and methods. A total of 373 women aged from 18 to 88 years were examined. Of these, 241 women were diagnosed with autoimmune thyroiditis. The remaining 132 women without thyroid pathology formed the control group. The groups were comparable by age. Molecular genetic testing included determination of genotypes and alleles of VDR rs1544410 (BsmI) gene polymorphism using real-time polymerase chain reaction. Results. There was no association between VDR rs1544410 gene polymorphism and autoimmune thyroiditis in the general group of examined women (p>0.05). The connection between the above genetic marker and thyroid pathology also was not found among postmenopausal women (p>0.05). At the same time analysis of VDR gene polymorphic variants in reproductive age women showed an associations of G allele and GG genotype of VDR gene rs1544410 (BsmI) polymorphism with autoimmune thyroiditis. Conclusion. The data obtained confirm the role of vitamin D metabolism in the etiopathogenesis of autoimmune thyroiditis and indicate the significance of rs1544410 polymorphism as a risk factor for the disease, taking into account the age factor.

Keywords

women, autoimmune thyroiditis, polymorphism, vitamin D receptor gene

About the Authors

Ivan A. Plakhotnikov

Donetsk State Medical University named after M. Gorky (DSMU named after M. Gorky)
Russian Federation

Dr. Sci. (Med.), Professor of the Department of Surgery, DSMU named after M. Gorky, Donetsk, Russian Federation

Yanina S. Valigun

Donetsk State Medical University named after M. Gorky (DSMU named after M. Gorky)
Russian Federation

Assistant at the Department of Transplantology and Clinical Laboratory Diagnostics, DSMU named after M. Gorky, Donetsk, Russian Federation

Eduard A. Maylyan

Donetsk State Medical University named after M. Gorky (DSMU named after M. Gorky)
Russian Federation

Dr. Sci. (Med.), Professor, Head of the Department of Microbiology, Virology, Immunology and Allergology, DSMU named after M. Gorky, Donetsk, Russian Federation

Ksenia E. Tkachenko

Donetsk State Medical University named after M. Gorky (DSMU named after M. Gorky)
Russian Federation

Cand. Sci. (Med.), Associate Professor at the Department of Microbiology, Virology, Immunology and Allergology, DSMU named after M. Gorky, Donetsk, Russian Federation

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Review

For citations:

Plakhotnikov I.A., Valigun Ya.S., Maylyan E.A., Tkachenko K.E. Association of vitamin D receptor rs1544410 gene polymorphism with autoimmune thyroiditis in women of reproductive age. Humans and their health. 2024;27(2):39-46. (In Russ.) https://doi.org/10.21626/vestnik/2024-2/05. EDN: NPTLZR

This work is licensed under a Creative Commons Attribution 4.0 License.

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ISSN 1998-5754 (Online)

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Humans and their health

Association of vitamin D receptor rs1544410 gene polymorphism with autoimmune thyroiditis in women of reproductive age

Full Text:

Abstract

Keywords

About the Authors

References

Review

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