Effects of the use of Imunofan and low-intensity la-ser radiation on immunological parameters in patients with true eczema

Objective: to study the serum levels of proinflammatory and anti-inflammatory cytokines in patients with true eczema against the background of standard treatment using imunofan and low-intensity laser radiation. Materials and methods. The study was performed with the participation of 132 patients with a moderate form of true eczema with a torpid course aged 18 to 70 years. The patients were divided into four groups: the first group received only standard therapy (Ct), the second group received Ct and imunofan (Im), the third group received Ct and sessions of intravenous laser irradiation of blood (NLOK), the fourth group received imunofan and NLOK sessions simultaneously against the background of standard therapy. The content of IL-4, -8, -18, -31 in blood serum was determined by solid-phase enzyme immunoassay before treatment, as well as 1 and 3 months after its onset. Results. Before the start of treatment, compared with healthy individuals, the levels of cytokines IL-8, -18, -31 were significantly higher (2.6-3.2 times), and IL-4 was 1.9 times lower. In the first group, cytokine levels did not significantly change at all follow-up periods. The use of immunophane and intravenous laser irradiation of blood caused a significant decrease in IL-8, -18, -31 levels and an increase in IL-4 levels 1 and 3 months after the start of treatment. The most pronounced character of these changes was observed with combined use against the background of standard immunophane therapy and intravenous laser irradiation of blood. At the same time, there were no significant differences in the levels of the studied cytokines 1 and 3 months after the start of treatment in any group. Conclusion. Treatment of patients with true eczema, including, along with standard therapy, intravenous laser irradiation of blood and imunofan, reduces the levels of blood cytokines IL-8, -18, -31 against the background of an increase in blood IL-4 levels.

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