Peculiarities of heavy metal and arsenic trans-medium transition along the chain "soil - medicinal plant material - water etracts"

Low-quality herbal raw materials and the products obtained from them are important sources of various ecotoxicants, especially heavy metals, entering the human body. Aqueous extractions of medicinal plant raw materials - decoctions and infusions - are of a particular interest in this respect - as they are the most accessible and frequently used dosage forms in medical and pharmaceutical practice and traditional medicine, being at present insufficiently studied as sources of intake of various microelements in the human body. Objective: to investigate the peculiarities of heavy metals and arsenic trans-mediated transition along the chain "soil - medicinal plant raw materials - infusions and decoctions". Materials and methods. Raw materials were harvested during the flowering period in Voronezh Biosphere Reserve. The microelement composition of the samples was studied by mass spectroscopy on an ELAN-DRC device. Results. The content of toxic microelements estimated in medicinal plant raw materials of natural phytocenosis of Voronezh region does not exceed the pharmacopoeial requirements, and their total proportion in the total mineral complex - not more than 0.011%. All made infusions and decoctions from the studied raw materials infusions and decoctions also corresponded to pharmacopoeial requirements on the content of normalized elements. The efficiency of cadmium transfer in infusions and decoctions from medicinal plant raw materials ranged from 9.02% to 55.00%, arsenic - from 26.33% to 68.46%, lead - from 1.95% to 76.15%. In the chain "soil - medicinal plant material - water extracts" normalized elements in LRS to the greatest extent migrated to the decoction of burdock root: cadmium - 74.91%, arsenic - 13.98%, lead - 6.02%. The lowest degree of transition was noted for the infusion of the studied flowers: for cadmium - 4.78%, arsenic - 0.46%, lead - 0.73%. Conclusion. The findings are of great interest and may serve both for further research and for using in medical and pharmaceutical practice.

1. D'yakova N.A. Accumulation in medicinal plant raw materials and extraction in infusions and decoctions of essential trace elements. Biofarmacevticheskij zhurnal. 2022;14(4):3-11 (in Russ.). DOI: 10.30906/2073-8099-2022-14-4-3-11. EDN: IBYNDK.

2. Popov A.I. Frontal elemental analysis of tansy flowers. Farmaciya. 1993;32(1):51-53. (in Russ.)

3. Popov A.I. Frontal elemental analysis of large plantain leaves. Himiko-farmacevticheskij zhurnal Khimiko-farmatsevticheskiy zhurnal. 1993;11:50-52 (in Russ.)

4. D'yakova N. A., Slivkin A. I., Gaponov S. P. Assessment of radionuclide contents in medicinal plant raw material of the central black-earth belt and their influence on accumulation of biologically active compounds. Pharmaceutical chemistry journal. 2020;54(6):626-630. DOI: 10.30906/0023-1134-2020-54-6-49-53. EDN: HPGDWJ

5. Popov A.I. Mineral substances grass mountain bird. Voprosy pitaniya. 1994;1(2):38-39 (in Russ.)

6. Rudaya M.A., Trineeva O.V., Slivkin A.I. Study of elemental composition of buckthorn fruits (Hippophae rhamnoides L.) of various varieties. Mikroelementy v medicine. 2018;19(3):49-59. (in Russ.). DOI: 10.19112/2413-6174-2018-19-3-49-59. EDN: YKVYOT.

7. D'yakova N.A., Slivkin A.I., Chupandina E.E., Gaponov S.P. Identification of permissible zones for preparation of medicinal vegetal raw materials near transport highways. Himiya rastitel'nogo syr'ya. 2020;(4):5-13 (in Russ.). DOI: 10.14258/jcprm.2020047609. EDN: KCCAGM.

8. Gravel' I.V., Ivashchenko N.V., Samylina I.A. Trace element composition of spasmolytic herbal tea and its components. Farmatsiya. 2011;(1):9-11 (in Russ.). EDN: NDCUNN

9. Gravel' I.V., Lyovushkin D.V., Miheev I.V., Skibina A.A. The amount of macroelements in the pectorales species No. 4 Traditsionnaya meditsina. 2021;3(66):19-26. (in Russ.). DOI: 10.54296/18186173_2021_3_19. EDN: IRPDTC.

10. Gravel' I.V., Nguen T.N.K., Alekseeva N.A., Tarasenko O.A. Investigation of the mineral composition of raw material and aqueous extracts from two species of mint (Mentha). Farmatsiya. 2013;(3):24-27 (in Russ.). EDN: QCNGVB.

11. D'yakova N.A. Accumulation of heavy metals by linden flowers of a heart-shaped linden growing in the agro- and urboecosystems of the Voronezh region. Trudy Karel’skogo nauchnogo tsentra Rossiyskoy akademii nauk. 2020;(5):70-79 (in Russ.). DOI: 10.17076/eco1150. EDN: BJRXVT

12. D'yakova N.A., Samylina I.A., Slivkin A.I., Gaponov S.P., Myndra A.A. Analysis of the relationship between the accumulation of pollutants and the main biologically active groups of substances in medicinal plant raw materials using the example of poultry mountain grass (Polygonum aviculare L.) and large plantain leaves (Plantago major L.). Himiko-farmacevticheskij zhurnal = Pharmaceutical Chemistry Journal. 2015;49(6):25-28.

13. Bayandina I.I., Zaguskaya Y.V. THE Relationship of secondary metabolism and chemical elements in medicinal plants. Sibirskij medicinskij zhurnal. 2014;(8):107-111 (in Russ.). EDN: TYSDNH.

14. Korolyov A.S., Gladyshev A.A., Yutkina I.S. Peculiarities of bioelements accumulation in the above-ground part of Artemisia absinthium L. on the slime field of the cryolite plant. News of the Orenburg State Agrarian University. 2014;5(49): 159-161 (in Russ.). EDN: TBRQRJ.

15. Wada O., Yanagisawa H. Trace elements, with special reference to the usefulness and safety of zinc. Medicine and Drug Journal. 1997;33(12):126-134.

16. Skal'nyj A. V., Skal'naya M.G., Kirichuk A.A., Tin'kov A.A. Medical elementology. Moscow: Nauka, 2021. 199 р. (in Russ.)

17. Kurkin V.A. Pharmacognosy. Samara: Ofort, 2004. 1179 р. (in Russ.)

18. State Pharmacopoeia of the Russian Federation. Edition XIV. Volume 4. Moscow: FEMB; 2018. 1883 р. (in Russ.)