Comparative characteristics of the parameters of the human corpus callosum in elderly and senile age established by the method of magnetic resonance tomography

Objective: to conduct a comparative analysis of age-related morphometric characteristics of the corpus callosum (callosometry) in elderly and senile age based on magnetic resonance imaging data. 

Materials and methods. The analysis of the results of a morphometric study of the corpus callosum of 97 people of both sexes (46 men and 51 women) who underwent a brain study in the Department of Radiation Diagnostics in the period 2019-2020 was carried out. Depending on the age, the subjects were divided into two groups. Group I included 52 elderly people (61-72 years old), and group II included 45 senile people (76-87 years old). All patients had no history of diseases and injuries of the Central and peripheral nervous system, as well as alcohol and drug dependence, but the predominance of the right hand (right-handed) was noted. All of them gave their consent to the magnetic resonance imaging examination, which was carried out only according to the indications. We determined the thickness of the genu, the thickness of the splenium, length and height of the corpus callosum, as well as its depth - anterior, superior and posterior. 

Results. When comparing the parameters of length and height of the corpus callosum, as well as all three parameters of depth, established in elderly and senile ages, statistically reliable age differences in the indices do not exist (p>0.05), but there is a tendency to reduce all their linear sizes from elderly to old age. When comparing the studied linear dimensions of the structural components of the corpus callosum (the thickness of the genu and the splenium) in elderly and senile ages, statistically significant differences in parameters were found with their predominance in the elderly (p<0.001).

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