Role of oxidative reactions changes in the pathogenesis of endothelial dysfunction of different severity in arterial hypertension
https://doi.org/10.21626/vestnik/2018-2/03
Abstract
In order to determine the role of products of lipid, peptides and nitro compounds oxidative metabolism in damages of vascular endothelium due to arterial hypertension (AH), 58 patients with AH aged 40-74 were examined by methods of endothelium dependent vasodilatation, enzyme immunoassay, spectrophotometry, determination of serum nitric oxide activity with Griss reagent. It was established that the severity of endothelial dysfunction against the background of hypertension depends on the intensity of oxidative reactions: at an early stage, intense oxidation of lipids takes place; Later, phase changes in the content of the nitrites and nitrotyrosine level are added. The progression of endothelial lesions in the initial stages is associated with the level of total oxidative activity, and at later stages with the concentration of oxidation products of peptides, which is of great diagnostic and prognostic value for evaluating the severity of endothelial damage as a target organ in hypertension.
About the Authors
N. K. Gorshunova
Kursk State Medical University
Russian Federation
Russian Federation
N. V. Medvedev
Kursk State Medical University
Russian Federation
Russian Federation
O. V. Rakhmanova
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Gorshunova N.K., Medvedev N.V., Rakhmanova O.V. Role of oxidative reactions changes in the pathogenesis of endothelial dysfunction of different severity in arterial hypertension. Kursk Scientific and Practical Bulletin "Man and His Health". 2018;(2):20-26. (In Russ.) https://doi.org/10.21626/vestnik/2018-2/03
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