Effect of transcranial electrical stimulation on adiponectin concentration in animals with a model of metabolic syndrome and sedentary lifestyle

Objective - to examine the impact of transcranial electrical stimulation on the dynamics of adiponectin concentration in blood in a rat model of metabolic syndrome and sedentary lifestyle.

Materials and methods. In the present study, experimental animals (n=180) comprised outbred male Wistar rats (age 10-12 weeks). These rats were divided into three groups. The control group (n=60) received a standard diet and were housed in cages with a seating density of at least 350 cm² per rat. The comparison group (n = 60) and the transcranial electrical stimulation group (n=60) were provided a high-fat and high-fructose diet, and cage density did not exceed 270 cm² per rat. In the transcranial electrical stimulation group, this procedure was performed daily for 30 minutes (current 0,6 mA). The adiponectin concentration in the blood of the animals was evaluated at 30, 60, and 90 days into the study.

Results. On the thirtieth day of the study, the estimated concentration was not statistically significantly different (p=0,5) between the groups. However, by day 60, the concentration in the transcranial electrical stimulation group exhibited a significant increase of 38.2% over the comparison group (p=0,008; effect size: ε2=0.2 (95% CI 0,04-0,5)). At the 90-day mark, the adiponectin concentration remained non-significantly different (p=0,5) between the groups.

Conclusion. This finding suggests that transcranial electrical stimulation may have an impact on adiponectin concentration in animals model of the discussed pathology. To provide a more comprehensive interpretation of the observed results, it is essential to consider the impact of transcranial electrostimulation on various parameters, including but not limited to: carbohydrate and lipid metabolism, the concentration of other adipokines, parainflammation, activation of anti-inflammatory systems (e.g. opioidergic) within the model of the aforementioned pathology.

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