Integral analysis of the effectiveness of spongy hemostatic polymer agents
https://doi.org/10.21626/vestnik/2025-1/02
EDN: ZDKGTB
Abstract
Objective - to conduct an integrated assessment of the main properties of spongy polymer hemostatic agents (SPHA) to select the most optimal option.
Materials and methods. Seven study groups were formed. The study assessed the degree of residual deformation of SPHA under 50% compression, the pore area and fiber thickness of the samples, their hygroscopicity, porosity, adhesion degree and hydrogen index. The next block of studies included in vivo methods. The thickness of the periprosthetic capsule, cellular index and hydroxyproline concentration in the implantation area of the study object were assessed. Hemostatic efficiency was assessed by determining the bleeding time and blood loss in an acute in vivo experiment, as well as the effect of SPHA on the clotting time of donor blood in vitro. The Kruskal-Wallis criterion was used to analyze the significance of differences between the experimental groups. An error value of 5% (p≤0.05 level) was considered acceptable for experimental biomedical studies. The licensed version of Statistica 13 and GraphPad Prism 9.5.1 were used as software.
Results. Ranking of material samples in the experimental, control and comparison groups (from the least to the most positive effect) made it possible to identify the material most beneficial for use in stopping bleeding by summing up their positions. This turned out to be the experimental sample of CMC + Collagen 25%, which scored the maximum sum of ranks - 83.
Conclusion. The maximum number of points according to the results of the integral rank assessment of the parameters of new multicomponent spongy polymer hemostatic agents was received by the sample containing 25% collagen, which allows us to judge the most optimal composition of the HPCS for further implementation in clinical medicine.
About the Author
Sergey V. Lazarenko
Kursk State Medical University (KSMU)
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Department of Urology, KSMU, Kursk, Russian Federation
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Review
For citations:
Lazarenko S.V. Integral analysis of the effectiveness of spongy hemostatic polymer agents. Humans and their health. 2025;28(1):13-20. (In Russ.) https://doi.org/10.21626/vestnik/2025-1/02. EDN: ZDKGTB
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