Cystatin C as an indicator of acute kidney injury in patients with thermal skin burns
https://doi.org/10.21626/vestnik/2024-4/05
EDN: RBCUFE
Abstract
Objective - to evaluate the dynamics of changes in the level of the biomarker of acute kidney injury - cystatin C in blood serum and urine in patients with thermal skin burns.
Materials and methods. The study included 74 patients with thermal skin burns of I-III degree with a skin lesion area of more than 25%, of which at least 15% are deep burns. Serum creatinine levels were determined using the kinetic Jaffe method. The concentration of cystatin C was studied by multiplex analysis on a flow cytofluorimeter.
Results. It was found that the concentration of cystatin C in the blood serum during burn shock increases by 1.9 times, with burn toxemia and septicotoxemia - by 1.5 times in relation to the control group. In urine, this indicator increases 17.4 times during burn shock, 17.1 times with burn toxemia and 15.8 times with septicotoxemia relative to the control group.
Conclusion. Cystatin C in serum and urine can be considered as an early biomarker of acute kidney injury in patients with thermal skin burns.
About the Authors
Alina A. Konovalova
Chita State Medical Academy (CSMA)
Russian Federation
Russian Federation
Viktor L. Tsepelev
Chita State Medical Academy (CSMA)
Russian Federation
Russian Federation
References
1. Chen B., Zhao J., Zhang Z., Li G., Jiang H., Huang Y., Li X. Clinical characteristics and risk factors for severe burns complicated by early acute kidney injury. Burns. 2020;46(5):1100-1106. DOI: 10.1016/j.burns.2019.11.018.
2. Shilova E.M., Smirnova A.V., Kozlovskaya N.L. Nephrology. Clinical recommendations. Moscow: GEOTAR Media, 2020. 856 p. (in Russ.)
3. Malyarchikov A.V., Shapovalov K.G., Lukyanov S.A., Tereshkov P.P., Kazantseva L.S. Acute renal injury in patients with pneumonia against the background of influenza A/H1N1. Acta Biomedica Scientifica. 2021;6(3):53-59 (in Russ.). DOI: 10.29413/ABS.2021-6.3.5. EDN: TNAXFN.
4. Khandelwal A., Satariano M., Doshi K., Aggarwal P., Avasarala V., Sood A., Bansal S., Neyra J.A., et al. Management and Outcomes of Acute Kidney Injury due to Burns: A Literature Review. J Burn Care Res. 2024;45(2):323-337. DOI: 10.1093/jbcr/irad121.
5. Desai R.J., Kazarov C.L., Wong A., Kane-Gill S.L. Kidney Damage and Stress Biomarkers for Early Identification of Drug-Induced Kidney Injury: A Systematic Review. Drug Saf. 2022;45(8):839-852. DOI: 10.1007/s40264-022-01202-2.
6. Benoit S.W., Ciccia E.A., Devarajan P. Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert Rev Mol Diagn. 2020;20(10):1019-1026. DOI: 10.1080/14737159.2020.1768849.
7. Korabelnikov D.I., Magomedaliev M.O. Modern biomarkers of acute kidney injury. Sovremennaya farmakoekonomika i farmakoepidemiologiya. 2023;16(1):87-104 (in Russ.). DOI: 10.17749/2070-4909/farmakoekonomika.2023.171. EDN: IMGXIE.
8. An J.N., Kim J.K., Lee H.S., Kim S.G., Kim H.J., Song Y.R. Serum cystatin C to creatinine ratio is associated with sarcopenia in non-dialysis-dependent chronic kidney disease. Kidney Res Clin Pract. 2022;41(5):580-590. DOI: 10.23876/j.krcp.21.214.
9. Haines R.W., Fowler A.J., Liang K., Pearse R.M., Larsson A.O., Puthucheary Z., Prowle J.R.Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness. Clin J Am Soc Nephrol. 2023;18(8):997-1005. DOI: 10.2215/CJN.0000000000000203.
10. Stehlé T., Delanaye P. Which is the best glomerular filtration marker: Creatinine, cystatin C or both? Eur J Clin Invest. 2024;54(10):e14278. DOI: 10.1111/eci.14278.
11. Mudrov V.A. Statistical analysis algorithms of quantitative features in biomedical researchusing the SPSS software package. Transbaikalian medical bulletin. 2020;(1):140-150 (in Russ.). DOI: 10.52485/19986173_2020_1_140. EDN: NXHHSU.
12. Mudrov V.A. Algorithms for performing data correlation analysis in biomedical research using the SPSS software package. Transbaikalian medical bulletin. 2020;(2):169-176 (in Russ.). DOI: 10.52485/19986173_2020_2_169. EDN: SPBMYO.
13. Visinescu A.M., Rusu E., Cosoreanu A., Radulian G. CYSTATIN C-A Monitoring Perspective of Chronic Kidney Disease in Patients with Diabetes.Int J Mol Sci. 2024;25(15):8135. DOI: 10.3390/ijms25158135.
14. Kawasaki Y., Nishiki K., Nojiri M., Kato R., Shinomiya S., Oikawa T., Ishizaki T., Toga H., et al. Prognostic value of the serum creatinine/cystatin C ratio in patients with chronic obstructive pulmonary disease. Respir Investig. 2024;62(1):143-149. DOI: 10.1016/j.resinv.2023.11.007.
15. Legrand M., Clark A.T., Neyra J.A., Ostermann M. Acute kidney injury in patients with burns. Nat Rev Nephrol. 2024;20(3):188-200. DOI: 10.1038/s41581-023-00769-y.
16. Chen D.C., Potok O.A., Rifkin D., Estrella M.M. Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR. Kidney360. 2022;3(10):1807-1814. DOI: 10.34067/KID.0003202022.
17. Khusainova M.A. Cystatin C is an early marker of decreased kidney function. Oriental renaissance: Innovative, educational, natural and social sciences. 2023;3(1):485-490 (in Russ.)
18. Linné E., Elfström A., Åkesson A., Fisher J., Grubb A., Pettilä V., Vaara S.T., Linder A., et al. Cystatin C and derived measures of renal function as risk factors for mortality and acute kidney injury in sepsis - A post-hoc analysis of the FINNAKI cohort. J Crit Care. 2022;72:154148. DOI: 10.1016/j.jcrc.2022.154148.
Review
For citations:
Konovalova A.A., Tsepelev V.L. Cystatin C as an indicator of acute kidney injury in patients with thermal skin burns. Humans and their health. 2024;24(4):50-56. (In Russ.) https://doi.org/10.21626/vestnik/2024-4/05. EDN: RBCUFE
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