Vitamin D and myostatin levels in postmenopausal women with stress urinary incontinence
https://doi.org/10.21626/vestnik/2024-4/03
EDN: FUOAVN
Abstract
Objective - to evaluate vitamin D and myostatin serum levels in postmenopausal women, and their associations with age, postmenopausal duration (PMD), and clinical severity of stress urinary incontinence (SUI).
Materials and methods. 150 postmenopausal women suffering from SUI were examined. Patients were interviewed using The Overactive Bladder Questionnaire. Serum concentrations of vitamin D and myostatin were studied.
Results. The subjective frequency of SUI symptoms in postmenopausal women increases with age and PMD (p=0,001 - p=0,045). Serum vitamin D concentrations decrease with age (p=0,004) and PMD (p=0,023). Serum myostatin levels increase with age (p=0,038). An increase in the age and PMD (p<0,0001), as well as reduced serum vitamin D concentrations (p<0,0001) and elevated myostatin levels (p=0,0004), are associated with a statistically significant decrease in the life quality of female patients with SUI.
Conclusions. The data obtained allow us to consider indicators of age and PMD, as well as serum concentrations of vitamin D and myostatin, as personalized predictors of deterioration in the life quality of women with SUI in the postmenopausal period.
About the Authors
Eduard A. Maylyan
M. Gorky Donetsk State Medical University (DonSMU)
Russian Federation
Russian Federation
Rudolf R. Gevorkyan
V.I. Vernadsky Crimean Federal University (V.I. Vernadsky CFU)
Russian Federation
Russian Federation
Natalya A. Reznichenko
V.I. Vernadsky Crimean Federal University (V.I. Vernadsky CFU)
Russian Federation
Russian Federation
Kseniya E. Tkachenko
M. Gorky Donetsk State Medical University (DonSMU)
Russian Federation
Russian Federation
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Review
For citations:
Maylyan E.A., Gevorkyan R.R., Reznichenko N.A., Tkachenko K.E. Vitamin D and myostatin levels in postmenopausal women with stress urinary incontinence. Humans and their health. 2024;24(4):31-38. (In Russ.) https://doi.org/10.21626/vestnik/2024-4/03. EDN: FUOAVN
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