Local treatment of purulent wounds with original wound dressings

Objective: to experimentally study the characteristics of the course of the wound process during local treatment of purulent wounds with developed wound coverings in the form of films. Materials and methods. Three wound dressings in the form of films containing antiseptics (miramistin, benzalkonium chloride, chlorhexidine bigluconate), an antimicrobial drug, an anesthetic and auxiliary components were developed. The experiment was performed on 108 rats, which were modeled with a purulent wound. The animals were divided into three equal groups, which differed in the method of wound treatment by one of the types of wound dressing. To assess the effectiveness of the wound process, planimetric parameters of wounds, pH, contamination with microorganisms, histological description of micropreparations were determined, morphometry with calculation of the cellular index was carried out. Intergroup determination of statistically significant differences, correlation and factor analysis were carried out. Results. The developed wound dressings had pronounced antimicrobial activity against S. aureus, E. coli and P. aeruginosa. In all experimental groups, the wound area by day 15 decreased by more than 98%, and the highest healing rate in the first three days was observed in the group where the wound dressing with miramistin was used. Bacterial contamination of wounds on the first day was more than 14x10⁷ CFU/g, at subsequent stages it was reduced, and by the 15^th day it was no longer observed. The cellular index on the 3^rd day was significantly higher in the group where the treatment was carried out with a wound dressing with benzalkonium chloride. According to the wound pH indicator, the group where the treatment was carried out with a wound dressing with miramistin had an advantage. Conclusion. A comprehensive assessment using factor analysis revealed that wound healing was most favorable in the group where treatment was carried out with a wound dressing containing miramistin, which allows us to recommend this wound dressing for further research.

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